Rafael Lorente de Nó

Rafael Lorente de Nó (April 8, 1902 – April 2, 1990) was a Spanish neuroscientist who advanced the scientific understanding of the nervous system with his seminal research. [1] [2] [3] He was a member of the National Academy of Sciences.[1][2] The National Academies Press called him "one of the premier neurophysiologists in the United States".[2]

Life and career

Lorente de Nó was born in Zaragoza, Spain. He received his medical degree from the University of Madrid in 1923.[2] He immigrated to the United States in 1931 when he accepted a position at the Central Institute for the Deaf in St. Louis.[1] In 1936 he joined The Rockefeller University, then known as The Rockefeller Institute for Medical Research, as an associate.[1] He was made an associate member in 1938 and a full member in 1941.[4][5] Lorente de Nó was an active member of several academic societies, among them the American Physiological Society and the American Association of Anatomists.[2]

Awards and distinctions

Lorente de Nó was elected to the National Academy of Sciences in 1950, and later also to the American Academy of Arts and Sciences.[1] He received honorary degrees from several universities, among them Clark University, Atlanta, and his home university, Rockefeller University, but also from University of Uppsala, Sweden.[2] His contributions to neuroscience were honored by the American Philosophical Society through the Karl Spencer Lashley Award in 1959; he was the first to receive this award.[6] In 1986, he received the Award of Merit for his life's work.

Notable research and discoveries
  • Seminal research of the structure and function of the cerebral cortex.[7] Maybe his most relevant contribution was the first description of the columnar organization of the brain cortex (well before Vernon Mountcastle and half a century before David Hubel and Torsten Wiesel were awarded with the Nobel Prize in Physiology or Medicine in 1981). He introduced the current terminology of the subfields of the cornu Ammonis of the hippocampus (CA1-4)[8] might be the most noteworthy.
  • Studies of the relationship between the nervous system the electrical and chemical basis of nerve functions[1]
  • Experiments that showed that nerves transmit electrical nerve impulses[9]
  • The first part of the scientific career of Rafael Lorente de Nó was focused in the histological study of the audio-vestibular nuclei and system, in general. He was invited by Robert Barany to work with him at Uppsala and was the founder of clinical Otorhinolaringlogy in Spain. Indeed, his first stage at the USA was to work in the Center for Deafness at the Washington University (St.-Louis, Missouri).
  • Description of the concept of `recurrent circuits´ well before others´ contributions (ex.: Alan Touring). The relevance of Lorente de Nó for modern cybernetics remains to be fully studied.
  • He synthesized tetraethyl ammonium (TEA) to block potassium channels.

References
  1. Rafael Lorente de No Dies of Cancer at 87; A Neural Researcher: April 06, 1990
  2. National Academies Press:Rafael Lorente De No, By Thomas A. Woolsey
  3. Kruger, Lawrence; Woolsey, Thomas A. (1990). "Rafael Lorente de Nó : 1902–1990". The Journal of Comparative Neurology. 300 (1): 1–4. doi:10.1002/cne.903000102. PMID 2229484.
  4. Science, American Association for the Advancement of (1938-07-08). "Appointments and Promotions at the Rockefeller Institute for Medical Research". Science. 88 (2271): 30–30. doi:10.1126/science.88.2271.30. ISSN 0036-8075.
  5. "Science: 93 (2426)". Science. 93 (2426). 1941-06-27. ISSN 0036-8075.
  6. List of award recipients at the APS website; retrieved August 4, 2013
  7. Rodríguez, J. J.; et al. "RAFAEL LORENTE de NÓ (1902-1990): THE PIONEER OF PHYSIOLOGYCAL NEUROANATOMY" (PDF). Federation of European Physiological Scientists. Cite journal requires |journal= (help)
  8. Lorente de Nó, Rafael (1934). "Studies on the structure of the cerebral cortex. II. Continuation of the study of the ammonic system". J Psychol Neurol. 46: 113–177.
  9. Lorente de Nó, Rafael (1939). "Transmission of Impulses through Cranial Motor Nuclei". Journal of Neurophysiology. 2: 402–464. doi:10.1152/jn.1939.2.5.402.


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