Regression (medicine)

Regression in medicine is a characteristic of diseases to decrease in severity and/or size.

• Clinically, regression generally refers to lighter symptoms without completely disappearing. At a later point, symptoms may return. These symptoms are then called recidive.

Mandard tumor regression grade (TRG), in this case showing rectal cancer.[1]

• In cancer, regression refers to a specific decrease in the size or extent of a tumour.[2] In histopathology, histological regression is one or more areas within a tumor in which neoplastic cells have disappeared or decreased in number.[3] In melanomas, this means complete or partial disappearance from areas of the dermis (and occasionally from the epidermis), which have been replaced by fibrosis, accompanied by melanophages, new blood vessels, and a variable degree of inflammation.[3]

References

1. Santos, Marisa D.; Silva, Cristina; Rocha, Anabela; Nogueira, Carlos; Castro-Poças, Fernando; Araujo, António; Matos, Eduarda; Pereira, Carina; Medeiros, Rui; Lopes, Carlos (2017). "Predictive clinical model of tumor response after chemoradiation in rectal cancer". Oncotarget. 8 (35). doi:10.18632/oncotarget.19651. ISSN 1949-2553.
   -Figure 3- available via license: Creative Commons Attribution 3.0 Unported
2. "Regression". NCI Dictionary of Cancer Terms. National Cancer Institute. Retrieved 31 August 2017.
3. Ribero, Simone; Gualano, Maria Rosaria; Osella-Abate, Simona; Scaioli, Giacomo; Bert, Fabrizio; Sanlorenzo, Martina; Balagna, Elena; Fierro, Maria Teresa; Macripò, Giuseppe; Sapino, Anna; Siliquini, Roberta; Quaglino, Pietro (2015). "Association of Histologic Regression in Primary Melanoma With Sentinel Lymph Node Status". JAMA Dermatology. 151 (12): 1301. doi:10.1001/jamadermatol.2015.2235. ISSN 2168-6068.