Relaxin/insulin-like family peptide receptor 3

Relaxin/insulin-like family peptide receptor 3, also known as RXFP3, is a human G-protein coupled receptor.[5]

RXFP3
Identifiers
Aliases	RXFP3, GPCR135, RLN3R1, RXFPR3, SALPR, Relaxin/insulin-like family peptide receptor 3, relaxin/insulin like family peptide receptor 3, relaxin family peptide receptor 3
External IDs	OMIM: 609445 MGI: 2441827 HomoloGene: 9568 GeneCards: RXFP3
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5p13.2 Start 33,936,386 bp[1] End 33,938,918 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 A1 Start 11,033,717 bp[2] End 11,037,991 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • G-protein coupled receptor activity • signal transducer activity • galanin receptor activity • G-protein coupled peptide receptor activity Cellular component • integral component of membrane • cell membrane • integral component of plasma membrane • membrane Biological process • positive regulation of cytokinesis • G-protein coupled receptor signaling pathway • phospholipase C-activating G-protein coupled receptor signaling pathway • positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway • signal transduction • adenylate cyclase-modulating G-protein coupled receptor signaling pathway • neuropeptide signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	51289	239336
Ensembl	ENSG00000182631 ENSG00000277069	ENSMUSG00000060735
UniProt	Q9NSD7	Q8BGE9
RefSeq (mRNA)	NM_016568	NM_178717
RefSeq (protein)	NP_057652	NP_848832
Location (UCSC)	Chr 5: 33.94 – 33.94 Mb	Chr 15: 11.03 – 11.04 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

See also

• Relaxin receptor

References

1. ENSG00000277069 GRCh38: Ensembl release 89: ENSG00000182631, ENSG00000277069 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000060735 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: RXFP3 relaxin/insulin-like family peptide receptor 3".

Further reading

• Bathgate RA, Ivell R, Sanborn BM, et al. (2005). "Receptors for relaxin family peptides". Ann. N. Y. Acad. Sci. 1041: 61–76. doi:10.1196/annals.1282.010. PMID 15956688. S2CID 1185573.
• Bathgate RA, Ivell R, Sanborn BM, et al. (2006). "International Union of Pharmacology LVII: recommendations for the nomenclature of receptors for relaxin family peptides". Pharmacol. Rev. 58 (1): 7–31. doi:10.1124/pr.58.1.9. PMID 16507880. S2CID 7466039.
• Matsumoto M, Kamohara M, Sugimoto T, et al. (2000). "The novel G-protein coupled receptor SALPR shares sequence similarity with somatostatin and angiotensin receptors". Gene. 248 (1–2): 183–9. doi:10.1016/S0378-1119(00)00123-2. PMID 10806363.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Liu C, Eriste E, Sutton S, et al. (2004). "Identification of relaxin-3/INSL7 as an endogenous ligand for the orphan G-protein-coupled receptor GPCR135". J. Biol. Chem. 278 (50): 50754–64. doi:10.1074/jbc.M308995200. PMID 14522968.
• Liu C, Chen J, Kuei C, et al. (2005). "Relaxin-3/insulin-like peptide 5 chimeric peptide, a selective ligand for G protein-coupled receptor (GPCR)135 and GPCR142 over leucine-rich repeat-containing G protein-coupled receptor 7". Mol. Pharmacol. 67 (1): 231–40. doi:10.1124/mol.104.006700. PMID 15465925. S2CID 25164369.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Van der Westhuizen ET, Sexton PM, Bathgate RA, Summers RJ (2005). "Responses of GPCR135 to human gene 3 (H3) relaxin in CHO-K1 cells determined by microphysiometry". Ann. N. Y. Acad. Sci. 1041: 332–7. doi:10.1196/annals.1282.053. PMID 15956730. S2CID 2468316.

External links

• "Relaxin Family Peptide Receptors: RXFP3". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.