Reza Dana

Reza Dana is the Claes H. Dohlman Professor of Ophthalmology, senior scientist and W. Clement Stone Clinical Research Scholar at Massachusetts Eye and Ear, Harvard Medical School, and director of the Harvard-Vision Clinical Scientist Development Program.[1]

Reza Dana
Reza Dana in 2019
EducationSt. Paul's School
Johns Hopkins University (BA, MD, MPH)
Illinois Eye and Ear Infirmary (Residency)
Wills Eye Hospital
Massachusetts Eye and Ear
Harvard University (MSc)
Known forDry Eye Disease
Corneal Transplantation Research
Medical career
FieldMedical research,
Immunology
Ophthalmology
InstitutionsMassachusetts Eye and Ear
Massachusetts General Hospital
Brigham and Women's Hospital
Harvard Medical School
Harvard University

Dana is an internationally recognized expert in the field of corneal disorders and ocular inflammation. He is best known for his work on the molecular and cellular mechanisms of ocular inflammation with translational applications to autoimmunity, transplantation, dry eye disease, and angiogenesis.[2] He is a member of editorial boards of 10 journals, including as editor-in-chief of Cornea.[3][4]

Education and training

Dana attended the Tehran International School during his early years and graduated summa cum laude from St. Paul's School, New Hampshire.[5] He pursued his baccalaureate degree at Johns Hopkins University School of Arts and Sciences, where he was invited to join the Phi Beta Kappa. Dr. Dana attended medical school at Johns Hopkins School of Medicine, and also obtained a master's degree in Public Health from Johns Hopkins Bloomberg School of Public Health.[6] He received his Ophthalmology residency training at the Illinois Eye and Ear Infirmary, and clinical cornea and external diseases fellowship at Wills Eye Hospital in Philadelphia. He received advanced fellowship training in Immunology and Uveitis at the Massachusetts Eye and Ear and pursued laboratory research training in Ocular and Transplantation Immunology Laboratory at the Schepens Eye Research Institute, Harvard Medical School under the mentorship of the late J. Wayne Streilein.[6]

Research and Career

Dana joined as an instructor in the department of ophthalmology at Harvard Medical School in 1995 and has been a faculty member here ever since. In 2006, he was named the director of Cornea Service at Massachusetts Eye and Ear, and in 2007, he was appointed the Claes H. Dohlman Chair in Ophthalmology and vice chairman for academic programs. He is also an honorary professor of ophthalmology at Shanghai Medical College, Fudan University.[7]

Dana's research focus is in the area of immuno-inflammatory disorders of the cornea and ocular surface. He has published over 370 peer-reviewed publications and over 150 reviews, edited several books and serves as the senior editor for Elsevier's Encyclopedia of the Eye.[8][9] His work has been cited more than 25000 times and carries an h-index of 82.[10] His is widely recognized for (i) identifying, phenotyping and functionally characterizing resident bone marrow-derived antigen-presenting cells (APC) of the cornea,[11] (ii) identifying novel mechanisms of corneal APC trafficking,[12] (iii) defining novel functional interactions between lymphatic endothelia and APC,[13] (iv) identifying selective topical cytokine and chemokine targeting to promote transplant survival by suppressing effector T cells,[14][15][16][17] (v) defining novel mechanisms employed by the corneal epithelium to maintain angiogenic privilege including the VEGFR-3 sink[18] and PD-L1 mechanisms,[19] (vi) developing strategies to promote corneal endothelial cell survival in transplantation, including gene therapy.[20][21]

Awards and honors
Dr.Joan Miller introducing Dana at the Friedenwald Award reception at Association for Research in Vision and Ophthalmology Annual Meeting 2018 in Honolulu.
Dana receiving the Ellis Island Medal of Honor in 2019

Teaching and Mentoring

Dana is the vice chair of academic programs at the Department of Ophthalmology, Massachusetts Eye and Ear and a faculty for the Graduate Program in Immunology, Harvard Medical School.[2] He is the recipient of the Harvard Medical School Clifford Barger Excellence in Mentoring Award, the top mentoring award bestowed at Harvard Medical School.[30] He has mentored over 120 postdoctoral research fellows from 33 countries, 80 clinical fellows and residents, medical students, and graduate students enrolled in Harvard Medical School. He is the director of the NIH-funded Harvard-Vision Clinical Scientist Development Program since 2004.[43]

References
  1. "Research Profile: Reza Dana, M.D., M.Sc., MPH | Mass. Eye and Ear". www.masseyeandear.org. Retrieved 2020-10-20.
  2. Research Profie: Reza Dana, MD, MSc, MPH
  3. Dana, Reza (2020). "Letter From the New Editor-in-Chief". Cornea. 39 (1): 1. doi:10.1097/ICO.0000000000002231. ISSN 1536-4798. PMID 31764283.
  4. "Reza Dana, MD, MSc, MPH, FARVO". eye.hms.harvard.edu. Retrieved 2020-10-20.
  5. Memarian, Jahandad (September 14, 2017). "Reza Dana: Success Begins Outside Your Comfort Zone". HuffPost. Retrieved 2020-10-20.
  6. Streilein, J. Wayne (2004-03-01). "Introducing Reza Dana, the 2003 Recipient of the Cogan Award". Investigative Ophthalmology & Visual Science. 45 (3): 721. doi:10.1167/iovs.03-0509. ISSN 1552-5783.
  7. "Dana CV" (PDF). Archived from the original (PDF) on 2019-11-08. Retrieved 2019-11-10.
  8. Dana, Reza. "Pubmed Bibliography". National Library of Medicine.
  9. Dana, Reza (2010). Encyclopedia of the Eye. Elsevier. ISBN 978-0-12-374198-1.
  10. "Google Scholar".
  11. Hamrah, Pedram; Huq, Syed O.; Liu, Ying; Zhang, Qiang; Dana, M. Reza (2003). "Corneal immunity is mediated by heterogeneous population of antigen-presenting cells". Journal of Leukocyte Biology. 74 (2): 172–178. doi:10.1189/jlb.1102544. ISSN 0741-5400. PMID 12885933. S2CID 15964172.
  12. Liu, Ying; Hamrah, Pedram; Zhang, Qiang; Taylor, Andrew W.; Dana, M. Reza (2002-01-21). "Draining Lymph Nodes of Corneal Transplant Hosts Exhibit Evidence for Donor Major Histocompatibility Complex (MHC) Class II–positive Dendritic Cells Derived from MHC Class II–negative Grafts". The Journal of Experimental Medicine. 195 (2): 259–268. doi:10.1084/jem.20010838. ISSN 0022-1007. PMC 2193609. PMID 11805152.
  13. Chen, Lu; Hamrah, Pedram; Cursiefen, Claus; Zhang, Qiang; Pytowski, Bronislaw; Streilein, J. Wayne; Dana, M. Reza (2004). "Vascular endothelial growth factor receptor-3 mediates induction of corneal alloimmunity". Nature Medicine. 10 (8): 813–815. doi:10.1038/nm1078. ISSN 1078-8956. PMID 15235599. S2CID 1449221.
  14. Huq, Syed; Liu, Ying; Benichou, Gilles; Dana, M. Reza (2004-10-01). "Relevance of the Direct Pathway of Sensitization in Corneal Transplantation Is Dictated by the Graft Bed Microenvironment". The Journal of Immunology. 173 (7): 4464–4469. doi:10.4049/jimmunol.173.7.4464. ISSN 0022-1767. PMID 15383577.
  15. Hattori, Takaaki; Saban, Daniel R.; Emami‐naeini, Parisa; Chauhan, Sunil K.; Funaki, Toshinari; Ueno, Hiroki; Dana, Reza (2012). "Donor-derived, tolerogenic dendritic cells suppress immune rejection in the indirect allosensitization-dominant setting of corneal transplantation". Journal of Leukocyte Biology. 91 (4): 621–627. doi:10.1189/jlb.1011500. ISSN 1938-3673. PMC 3317274. PMID 22291211.
  16. Dohlman, Thomas; Omoto, Masahiro; Hua, Jing; Stevenson, William; Lee, Sang-Mok; Chauhan, Sunil; Dana, Reza (2015). "VEGF-trap Aflibercept Significantly Improves Long-term Graft Survival in High-risk Corneal Transplantation". Transplantation. 99 (4): 678–686. doi:10.1097/TP.0000000000000512. ISSN 0041-1337. PMID 25606789. S2CID 26944722.
  17. Amouzegar, Afsaneh; Chauhan, Sunil K.; Dana, Reza (2016-05-15). "Alloimmunity and Tolerance in Corneal Transplantation". The Journal of Immunology. 196 (10): 3983–3991. doi:10.4049/jimmunol.1600251. ISSN 0022-1767. PMC 4874505. PMID 27183635.
  18. Cursiefen, Claus; Chen, Lu; Saint-Geniez, Magali; Hamrah, Pedram; Jin, Yiping; Rashid, Saadia; Pytowski, Bronislaw; Persaud, Kris; Wu, Yan; Streilein, J. Wayne; Dana, Reza (2006-07-25). "Nonvascular VEGF receptor 3 expression by corneal epithelium maintains avascularity and vision". Proceedings of the National Academy of Sciences of the United States of America. 103 (30): 11405–11410. Bibcode:2006PNAS..10311405C. doi:10.1073/pnas.0506112103. ISSN 0027-8424. PMC 1544098. PMID 16849433.
  19. Shen, Linling; Jin, Yiping; Freeman, Gordon J.; Sharpe, Arlene H.; Dana, M. Reza (2007-09-15). "The function of donor versus recipient programmed death-ligand 1 in corneal allograft survival". Journal of Immunology. 179 (6): 3672–3679. doi:10.4049/jimmunol.179.6.3672. ISSN 0022-1767. PMID 17785803.
  20. Fuchsluger, T. A.; Jurkunas, U.; Kazlauskas, A.; Dana, R. (2011). "Anti-apoptotic gene therapy prolongs survival of corneal endothelial cells during storage". Gene Therapy. 18 (8): 778–787. doi:10.1038/gt.2011.20. ISSN 1476-5462. PMC 3587653. PMID 21412281.
  21. Fuchsluger, Thomas A.; Jurkunas, Ula; Kazlauskas, Andrius; Dana, Reza (2011). "Corneal endothelial cells are protected from apoptosis by gene therapy". Human Gene Therapy. 22 (5): 549–558. doi:10.1089/hum.2010.079. ISSN 1557-7422. PMC 3081440. PMID 21158568.
  22. "Heed Fellows || The Heed Foundation". www.heed.org. Retrieved 2020-10-20.
  23. "Honors and Distinctions - Schepens Eye Research Institute of Mass. Eye and Ear". www.schepens.harvard.edu. Archived from the original on 2019-11-10. Retrieved 2019-11-10.
  24. "Reza Dana | Harvard Catalyst Profiles | Harvard Catalyst". connects.catalyst.harvard.edu. Retrieved 2020-10-20.
  25. "Alcon Research Institute Past Grant Recipients | MyAlcon.com". www.myalcon.com. Archived from the original on 2019-11-10. Retrieved 2019-11-10.
  26. "Ever Association". www.everassociation.org. Retrieved 2020-10-20.
  27. "LSUHSC School of Medicine". www.medschool.lsuhsc.edu. Retrieved 2020-10-20.
  28. "The Association for Research in Vision and Ophthalmology- 2013 ARVO Fellows". www.arvo.org. Retrieved 2020-10-20.
  29. "Ocular Microbiology and Immunology Group, Inc". Ocular Microbiology and Immunology Group, Inc. Retrieved 2020-10-20.
  30. "A. Clifford Barger Excellence in Mentoring Award Recipients". The Office for Diversity Inclusion and Community Partnership at Harvard Medical School. Retrieved 2020-10-20.
  31. "Reza Dana, MD, MSc, MPH, Receives Kersley Medal". eye.hms.harvard.edu. Retrieved 2020-10-20.
  32. "Roger F. Meyer Lectureship in Cornea | Ophthalmology | Michigan Medicine". Ophthalmology. 2017-08-28. Retrieved 2020-10-20.
  33. "Reza Dana Elected to Academia Ophthalmologica Internationalis". eye.hms.harvard.edu. Retrieved 2020-10-20.
  34. "Honorary Lectures + ICO Medal Winners | Eye Doctors ©2019". entertainment.ie. Retrieved 2019-11-10.
  35. "Dr. Reza Dana to Receive 2016 Endre A. Balazs Prize". eye.hms.harvard.edu. 2016-04-28. Retrieved 2020-10-20.
  36. "The 121st Annual Meeting of the Japanese Ophthalmological Society". convention.jtbcom.co.jp. Retrieved 2020-10-20.
  37. "Reza Dana receives Senior Achievement Award from AAO". eye.hms.harvard.edu. Retrieved 2020-10-20.
  38. Jurkunas, Ula. "30th Biennial Cornea Conference". Grantome.
  39. "Dr. Reza Dana to receive Friedenwald Award from the Association for Research in Vision and Ophthalmology". eye.hms.harvard.edu. 2017-06-02. Retrieved 2019-11-10.
  40. "Reza Dana, MD, MSc, MPH, Awarded Research to Prevent Blindness Stein Innovation Award". eye.hms.harvard.edu. 2018-06-25. Retrieved 2020-10-20.
  41. "2019 Ellis Island Medal of Honor Recipients". eihonors.org. Retrieved 2020-10-20.
  42. "Reza Dana". The Ophthalmologist. Retrieved 2020-10-20.
  43. "Reza Dana, MD, MSc, MPH". Harvard Medical School. Retrieved 2020-10-20.
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