Ribosomal protein L13 leader
L13 ribosomal protein leaders are part of the ribosome biogenesis. They are used as an autoregulatory mechanism to control the concentration of ribosomal proteins L13. An experimentally confirmed ribosomal protein leader autoregulatory structure[1] was found in B. subtilis and other low-GC Gram-positive bacteria. It is located in the 5′ untranslated regions of mRNAs encoding the L13-S9 (rplM-rpsI) ribosomal protein operon.[1] A second example were predicted in Bacteroidia with bioinformatic approaches,[2] but the structure of the putative Bacteroidia example is apparently unrelated to the previously established L13 ribosomal protein leader.
| L13_leader | |
|---|---|
 Consensus secondary structure and sequence conservation of Ribosomal protein L13 leader | |
| Identifiers | |
| Symbol | L13_leader |
| Rfam | RF00555 |
| Other data | |
| RNA type | Cis-reg; leader |
| GO | GO:0010468 |
| SO | SO:0000233 |
| PDB structures | PDBe |
| L13-Bacteroidia | |
|---|---|
 Consensus secondary structure and sequence conservation of L13-Bacteroidia ribosomal protein leader | |
| Identifiers | |
| Symbol | L13-Bacteroidia |
| Rfam | RF03127 |
| Other data | |
| RNA type | Cis-reg; leader |
| SO | SO:0000837 |
| PDB structures | PDBe |
References
- Zengel JM, Lindahl L (1994). Diverse mechanisms for regulating ribosomal protein synthesis in Escherichia coli. Progress in Nucleic Acid Research and Molecular Biology. 47. pp. 331–370. doi:10.1016/S0079-6603(08)60256-1. ISBN 978-0-12-540047-3. PMID 7517053.
- Eckert, I; Weinberg, Z (24 May 2020). "Discovery of 20 novel ribosomal leader candidates in bacteria and archaea". BMC Microbiology. 20 (130): 130. doi:10.1186/s12866-020-01823-6. PMC 7247131. PMID 32448158.
External links
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