Ribosomal protein L19 leader

L19 Ribosomal protein leaders are part of the ribosome biogenesis. They were used as an autoregulatory mechanism to control the concentration of ribosomal proteins L19. This family is a putative ribosomal protein leader autoregulatory structure[1] found in B. subtilis and other low-GC Gram-positive bacteria. It is located in the 5′ untranslated regions of mRNAs encoding ribosomal protein L19 (rplS). More examples were predicted in Flavobacteria[2] or Firmicutes[3] with bioinformatic approaches. The structures of all these predicted L19 ribosomal leaders are similar.

L19_leader
Consensus secondary structure and sequence conservation of Ribosomal protein L19 leader
Identifiers
SymbolL19_leader
RfamRF00556
Other data
RNA type Cis-reg; leader
GOGO:0010468
SOSO:0000233
PDB structuresPDBe
L19-Flavobacteria
Consensus secondary structure and sequence conservation of L19-Flavobacteria ribosomal protein leader
Identifiers
SymbolL19-Flavobacteria
RfamRF03130
Other data
RNA type Cis-reg; leader
SOSO:0000837
PDB structuresPDBe

See also

References
  1. Zengel JM, Lindahl L (1994). Diverse mechanisms for regulating ribosomal protein synthesis in Escherichia coli. Progress in Nucleic Acid Research and Molecular Biology. 47. pp. 331–370. doi:10.1016/S0079-6603(08)60256-1. ISBN 978-0-12-540047-3. PMID 7517053.
  2. Eckert, I; Weinberg, Z (24 May 2020). "Discovery of 20 novel ribosomal leader candidates in bacteria and archaea". BMC Microbiology. 20 (130): 130. doi:10.1186/s12866-020-01823-6. PMC 7247131. PMID 32448158.
  3. Yao, Z; Barrick, J; Weinberg, Z; Neph, S; Breaker, R; Tompa, M; Ruzzo, WL (2007). "A computational pipeline for high-throughput discovery of cis-regulatory noncoding RNA in prokaryotes". PLOS Computational Biology. 3 (7): e126. Bibcode:2007PLSCB...3..126Y. doi:10.1371/journal.pcbi.0030126. PMC 1913097. PMID 17616982.
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