RyeE RNA
The CyaR RNA (formerly known as RyeE RNA) non-coding RNA was identified in a large scale screen of Escherichia coli and was called candidate 14.[1] The exact 5′ and 3′ ends of this RNA are uncertain. This gene lies between yegQ and orgK in E. coli. This small RNA was shown to be bound by the Hfq protein. This RNA has been renamed as CyaR for (cyclic AMP-activated RNA). It has been shown that the CyaR RNA acts as a repressor of the porin OmpX.[2] It has also been shown that cyaR expression is tightly controlled by the cyclic AMP receptor protein, CRP.[2]
| CyaR/Rye RNA | |
|---|---|
 Predicted secondary structure and sequence conservation of CyaR_RyeE | |
| Identifiers | |
| Symbol | CyaR_RyeE |
| Alt. Symbols | RyeE |
| Rfam | RF00112 |
| Other data | |
| RNA type | Gene; sRNA |
| Domain(s) | Bacteria |
| SO | SO:0000655 |
| PDB structures | PDBe |
A comparative genomics approach was able to detect and verify the additional targets ptsI, sdhA and yobF.[3]
References
- Wassarman, KM; Repoila F; Rosenow C; Storz G; Gottesman S (2001). "Identification of novel small RNAs using comparative genomics and microarrays". Genes Dev. 15 (13): 1637–1651. doi:10.1101/gad.901001. PMC 312727. PMID 11445539.
- Papenfort K, Pfeiffer V, Lucchini S, Sonawane A, Hinton JC, Vogel J (May 2008). "Systematic deletion of Salmonella small RNA genes identifies CyaR, a conserved CRP-dependent riboregulator of OmpX synthesis". Mol. Microbiol. 68 (4): 890–906. doi:10.1111/j.1365-2958.2008.06189.x. PMID 18399940. S2CID 18442940.
- Wright PR, Richter AS, Papenfort K, Mann M, Vogel J, Hess WR, Backofen R, Georg J (2013). "Comparative genomics boosts target prediction for bacterial small RNAs". Proc Natl Acad Sci U S A. 110 (37): E3487–E3496. doi:10.1073/pnas.1303248110. PMC 3773804. PMID 23980183.
External links
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