S100A5

S100 calcium-binding protein A5 (S100A5) is a protein that in humans is encoded by the S100A5 gene.[5][6]

S100A5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2KAX, 2KAY, 4DIR
Identifiers
Aliases	S100A5, S100D, S100 calcium binding protein A5
External IDs	OMIM: 176991 MGI: 1338915 HomoloGene: 2224 GeneCards: S100A5
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q21.3 Start 153,537,147 bp[1] End 153,541,765 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3 F1|3 39.27 cM Start 90,608,523 bp[2] End 90,611,780 bp[2]
RNA expression pattern More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6276	20199
Ensembl	ENSG00000196420	ENSMUSG00000001023
UniProt	P33763	P63084
RefSeq (mRNA)	NM_002962	NM_011312
RefSeq (protein)	NP_002953	NP_035442
Location (UCSC)	Chr 1: 153.54 – 153.54 Mb	Chr 3: 90.61 – 90.61 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein has a Ca²⁺ affinity 20- to 100-fold higher than the other S100 proteins studied under identical conditions. This protein also binds Zn²⁺ and Cu²⁺, and Cu²⁺ strongly which impairs the binding of Ca²⁺. This protein is expressed in very restricted regions of the adult brain.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000196420 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000001023 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Engelkamp D, Schafer BW, Mattei MG, Erne P, Heizmann CW (Aug 1993). "Six S100 genes are clustered on human chromosome 1q21: identification of two genes coding for the two previously unreported calcium-binding proteins S100D and S100E". Proc Natl Acad Sci U S A. 90 (14): 6547–51. Bibcode:1993PNAS...90.6547E. doi:10.1073/pnas.90.14.6547. PMC 46969. PMID 8341667.
6. "Entrez Gene: S100A5 S100 calcium binding protein A5".

Further reading

• Schäfer BW, Heizmann CW (1996). "The S100 family of EF-hand calcium-binding proteins: functions and pathology". Trends Biochem. Sci. 21 (4): 134–40. doi:10.1016/S0968-0004(96)80167-8. PMID 8701470.
• Schäfer BW, Wicki R, Engelkamp D, et al. (1995). "Isolation of a YAC clone covering a cluster of nine S100 genes on human chromosome 1q21: rationale for a new nomenclature of the S100 calcium-binding protein family". Genomics. 25 (3): 638–43. doi:10.1016/0888-7543(95)80005-7. PMID 7759097.
• Ridinger K, Ilg EC, Niggli FK, et al. (1999). "Clustered organization of S100 genes in human and mouse". Biochim. Biophys. Acta. 1448 (2): 254–63. doi:10.1016/S0167-4889(98)00137-2. PMID 9920416.
• Schäfer BW, Fritschy JM, Murmann P, et al. (2000). "Brain S100A5 is a novel calcium-, zinc-, and copper ion-binding protein of the EF-hand superfamily". J. Biol. Chem. 275 (39): 30623–30. doi:10.1074/jbc.M002260200. PMID 10882717.
• Bronckart Y, Decaestecker C, Nagy N, et al. (2002). "Development and progression of malignancy in human colon tissues are correlated with expression of specific Ca(2+)-binding S100 proteins". Histol. Histopathol. 16 (3): 707–12. PMID 11510959.
• Teratani T, Watanabe T, Yamahara K, et al. (2002). "Restricted expression of calcium-binding protein S100A5 in human kidney". Biochem. Biophys. Res. Commun. 291 (3): 623–7. doi:10.1006/bbrc.2002.6494. PMID 11855835.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Chan WY, Xia CL, Dong DC, et al. (2003). "Differential expression of S100 proteins in the developing human hippocampus and temporal cortex". Microsc. Res. Tech. 60 (6): 600–13. doi:10.1002/jemt.10302. PMID 12645008. S2CID 13596098.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.