SAMD4A

Sterile alpha motif domain containing 4A is a protein that in humans is encoded by the SAMD4A gene. [5]

SAMD4A
Identifiers
Aliases	SAMD4A, SAMD4, SMAUG, SMAUG1, SMG, SMGA, sterile alpha motif domain containing 4A
External IDs	OMIM: 610747 MGI: 1921730 HomoloGene: 19167 GeneCards: SAMD4A
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q22.2 Start 54,567,097 bp[1] End 54,793,315 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 C1 Start 46,882,854 bp[2] End 47,105,815 bp[2]
Gene ontology Molecular function • GO:0001948 protein binding • translation repressor activity • mRNA binding • RNA binding Cellular component • cytoplasm • neuron projection • dendrite • cell projection • synapse • P-body • fibrillar center • cytosol • cell junction Biological process • regulation of translation • positive regulation of translation • negative regulation of translation • nuclear-transcribed mRNA poly(A) tail shortening • regulation of mRNA stability • regulation of transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	23034	74480
Ensembl	ENSG00000020577	ENSMUSG00000021838
UniProt	Q9UPU9	Q8CBY1
RefSeq (mRNA)	NM_015589 NM_001161576 NM_001161577	NM_001037221 NM_001163433 NM_028966 NM_001310544
RefSeq (protein)	NP_001155048 NP_001155049 NP_056404	NP_001032298 NP_001156905 NP_001297473 NP_083242
Location (UCSC)	Chr 14: 54.57 – 54.79 Mb	Chr 14: 46.88 – 47.11 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

Sterile alpha motifs (SAMs) in proteins such as SAMD4A are part of an RNA-binding domain that functions as a posttranscriptional regulator by binding to an RNA sequence motif known as the Smaug recognition element, which was named after the Drosophila Smaug protein (Baez and Boccaccio, 2005 [PubMed 16221671]).[supplied by OMIM, Mar 2008].

References

1. GRCh38: Ensembl release 89: ENSG00000020577 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000021838 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Sterile alpha motif domain containing 4A". Retrieved 2020-04-16.

Further reading

• Baez MV, Boccaccio GL (December 2005). "Mammalian Smaug is a translational repressor that forms cytoplasmic foci similar to stress granules". J. Biol. Chem. 280 (52): 43131–40. doi:10.1074/jbc.M508374200. PMID 16221671.
• Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD (November 2009). "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip". Am. J. Hum. Genet. 85 (5): 628–42. doi:10.1016/j.ajhg.2009.10.014. PMC 2775832. PMID 19913121.
• Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
• Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S (October 2010). "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study". Diabetes Care. 33 (10): 2250–3. doi:10.2337/dc10-0452. PMC 2945168. PMID 20628086.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.