SASH1

SAM and SH3 domain-containing protein 1 is a protein that in humans is encoded by the SASH1 gene.[5][6][7]

SASH1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2EBP
Identifiers
Aliases	SASH1, SH3D6A, dJ323M4, dJ323M4.1, SAM and SH3 domain containing 1, DUH1, CAPOK
External IDs	OMIM: 607955 MGI: 1917347 HomoloGene: 69182 GeneCards: SASH1
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q24.3-q25.1 Start 148,272,304 bp[1] End 148,552,048 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 A1 Start 8,722,219 bp[2] End 8,886,070 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • mitogen-activated protein kinase kinase kinase binding • GO:0032947 molecular adaptor activity • protein C-terminus binding • protein kinase binding Cellular component • macromolecular complex Biological process • positive regulation of endothelial cell migration • positive regulation of lipopolysaccharide-mediated signaling pathway • positive regulation of JUN kinase activity • regulation of protein K63-linked ubiquitination • positive regulation of p38MAPK cascade • regulation of protein autoubiquitination • protein polyubiquitination • positive regulation of NIK/NF-kappaB signaling • positive regulation of angiogenesis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	23328	70097
Ensembl	ENSG00000111961	ENSMUSG00000015305
UniProt	O94885	P59808
RefSeq (mRNA)	NM_015278 NM_001346505 NM_001346506 NM_001346507 NM_001346508 NM_001346509	NM_175155
RefSeq (protein)	NP_001333434 NP_001333435 NP_001333436 NP_001333437 NP_001333438 NP_056093	NP_780364
Location (UCSC)	Chr 6: 148.27 – 148.55 Mb	Chr 10: 8.72 – 8.89 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000111961 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000015305 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Apr 1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.
6. Zeller C, Hinzmann B, Seitz S, Prokoph H, Burkhard-Goettges E, Fischer J, Jandrig B, Schwarz LE, Rosenthal A, Scherneck S (May 2003). "SASH1: a candidate tumor suppressor gene on chromosome 6q24.3 is downregulated in breast cancer". Oncogene. 22 (19): 2972–83. doi:10.1038/sj.onc.1206474. PMID 12771949.
7. "Entrez Gene: SASH1 SAM and SH3 domain containing 1".

Further reading

• Rimkus C, Martini M, Friederichs J, et al. (2007). "Prognostic significance of downregulated expression of the candidate tumour suppressor gene SASH1 in colon cancer". Br. J. Cancer. 95 (10): 1419–23. doi:10.1038/sj.bjc.6603452. PMC 2360597. PMID 17088907.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
• Cheng J, Kapranov P, Drenkow J, et al. (2005). "Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution". Science. 308 (5725): 1149–54. doi:10.1126/science.1108625. PMID 15790807. S2CID 13047538.
• Benzinger A, Muster N, Koch HB, et al. (2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Mol. Cell. Proteomics. 4 (6): 785–95. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.