SCMH1

Polycomb protein SCMH1 is a protein that in humans is encoded by the SCMH1 gene.[5][6]

SCMH1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2P0K
Identifiers
Aliases	SCMH1, Scml3, sex comb on midleg homolog 1 (Drosophila), Scm polycomb group protein homolog 1
External IDs	OMIM: 616396 MGI: 1352762 HomoloGene: 32146 GeneCards: SCMH1
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p34.2 Start 41,027,200 bp[1] End 41,242,154 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 D2.1-D2.2|4 56.52 cM Start 120,405,281 bp[2] End 120,530,186 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding Cellular component • chromocenter • nucleoplasm • cell nucleus Biological process • multicellular organism development • gene silencing • chromatin remodeling • regulation of transcription, DNA-templated • transcription, DNA-templated • spermatogenesis • anterior/posterior pattern specification • negative regulation of transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	22955	29871
Ensembl	ENSG00000010803	ENSMUSG00000000085
UniProt	Q96GD3	Q8K214
RefSeq (mRNA)	NM_001031694 NM_001172218 NM_001172219 NM_001172220 NM_001172221 NM_001172222 NM_012236 NM_001350667 NM_001350668	NM_001159630 NM_013883 NM_001355423 NM_001355424 NM_001379184 NM_001379185 NM_001379186
RefSeq (protein)	NP_001026864 NP_001165689 NP_001165690 NP_001165691 NP_001165692 NP_001165693 NP_036368 NP_001337596 NP_001337597	NP_001153102 NP_038911 NP_001342352 NP_001342353 NP_001366113 NP_001366114 NP_001366115
Location (UCSC)	Chr 1: 41.03 – 41.24 Mb	Chr 4: 120.41 – 120.53 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000010803 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000000085 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Berger J, Kurahashi H, Takihara Y, Shimada K, Brock HW, Randazzo F (September 1999). "The human homolog of Sex comb on midleg (SCMH1) maps to chromosome 1p34". Gene. 237 (1): 185–91. doi:10.1016/S0378-1119(99)00285-1. PMID 10524249.
6. "Entrez Gene: SCMH1 sex comb on midleg homolog 1 (Drosophila)".

Further reading

• Tomotsune D, Takihara Y, Berger J, Duhl D, Joo S, Kyba M, Shirai M, Ohta H, Matsuda Y, Honda BM, Simon J, Shimada K, Brock HW, Randazzo F (December 1999). "A novel member of murine Polycomb-group proteins, Sex comb on midleg homolog protein, is highly conserved, and interacts with RAE28/mph1 in vitro". Differentiation; Research in Biological Diversity. 65 (4): 229–39. doi:10.1046/j.1432-0436.1999.6540229.x. PMID 10653359.
• Levine SS, Weiss A, Erdjument-Bromage H, Shao Z, Tempst P, Kingston RE (September 2002). "The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans". Molecular and Cellular Biology. 22 (17): 6070–8. doi:10.1128/MCB.22.17.6070-6078.2002. PMC 134016. PMID 12167701.
• Luo L, Yang X, Takihara Y, Knoetgen H, Kessel M (February 2004). "The cell-cycle regulator geminin inhibits Hox function through direct and polycomb-mediated interactions". Nature. 427 (6976): 749–53. Bibcode:2004Natur.427..749L. doi:10.1038/nature02305. hdl:11858/00-001M-0000-0012-EE32-1. PMID 14973489. S2CID 8020382.
• Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (September 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
• Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (May 2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.