SEC23B

Protein transport protein Sec23B is a protein that in humans is encoded by the SEC23B gene.[5][6][7]

SEC23B
Identifiers
Aliases	SEC23B, CDA-II, CDAII, CDAN2, HEMPAS, CWS7, Sec23 homolog B, coat complex II component, hSec23B, SEC23 homolog B, COPII coat complex component
External IDs	OMIM: 610512 MGI: 1350925 HomoloGene: 74571 GeneCards: SEC23B
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20p11.23 Start 18,507,520 bp[1] End 18,561,415 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 G1 Start 144,556,229 bp[2] End 144,590,749 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • zinc ion binding • GO:0001948 protein binding • metal ion binding • GO:0005097, GO:0005099, GO:0005100 GTPase activator activity Cellular component • perinuclear region of cytoplasm • COPII vesicle coat • endoplasmic reticulum membrane • endomembrane system • endoplasmic reticulum • membrane • cytoplasm • cytosol • ER to Golgi transport vesicle membrane • cytoplasmic vesicle • Golgi membrane • endoplasmic reticulum exit site Biological process • protein transport • ER to Golgi vesicle-mediated transport • intracellular protein transport • vesicle-mediated transport • COPII-coated vesicle budding • regulation of COPII vesicle coating • Golgi organization • regulation of cell shape • macroautophagy • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity • cargo loading into COPII-coated vesicle Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10483	27054
Ensembl	ENSG00000101310	ENSMUSG00000027429
UniProt	Q15437 Q5QPE2	Q9D662
RefSeq (mRNA)	NM_032986 NM_001172745 NM_001172746 NM_006363 NM_032985	NM_001252543 NM_001252544 NM_001252545 NM_001281816 NM_019787 NM_001355379 NM_001355380
RefSeq (protein)	NP_001166216 NP_001166217 NP_006354 NP_116780 NP_116781	NP_001239472 NP_001239473 NP_001239474 NP_001268745 NP_062761 NP_001342308 NP_001342309
Location (UCSC)	Chr 20: 18.51 – 18.56 Mb	Chr 2: 144.56 – 144.59 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene is a member of the SEC23 subfamily of the SEC23/SEC24 family, which is involved in vesicle trafficking. The encoded protein has similarity to yeast Sec23p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The function of this gene product has been implicated in cargo selection and concentration.

Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.[7] Mutations in SEC23B cause an autosomal recessive disorder called congenital dyserythropoietic anemia type II (CDAII).

References

1. GRCh38: Ensembl release 89: ENSG00000101310 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027429 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Paccaud JP, Reith W, Carpentier JL, Ravazzola M, Amherdt M, Schekman R, Orci L (Mar 1997). "Cloning and functional characterization of mammalian homologues of the COPII component Sec23". Mol Biol Cell. 7 (10): 1535–46. doi:10.1091/mbc.7.10.1535. PMC 276004. PMID 8898360.
6. Tang BL, Kausalya J, Low DY, Lock ML, Hong W (Jun 1999). "A family of mammalian proteins homologous to yeast Sec24p". Biochem Biophys Res Commun. 258 (3): 679–84. doi:10.1006/bbrc.1999.0574. PMID 10329445.
7. "Entrez Gene: SEC23B Sec23 homolog B (S. cerevisiae)".

Further reading

• Pagano A, Letourneur F, Garcia-Estefania D, et al. (1999). "Sec24 proteins and sorting at the endoplasmic reticulum". J. Biol. Chem. 274 (12): 7833–40. doi:10.1074/jbc.274.12.7833. PMID 10075675.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Oh JH, Yang JO, Hahn Y, et al. (2006). "Transcriptome analysis of human gastric cancer". Mamm. Genome. 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674. S2CID 69278.