SEC23IP

SEC23-interacting protein is a protein that in humans is encoded by the SEC23IP gene.[5][6]

SEC23IP
Identifiers
Aliases	SEC23IP, P125, P125A, MSTP053, SEC23 interacting protein
External IDs	OMIM: 617852 MGI: 2450915 HomoloGene: 38288 GeneCards: SEC23IP
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q26.11-q26.12 Start 119,892,730 bp[1] End 119,944,657 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 F3|7 70.51 cM Start 128,744,943 bp[2] End 128,784,836 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • metal ion binding • phospholipase activity • RNA binding Cellular component • cytoplasm • ER to Golgi transport vesicle membrane • cytosol • endoplasmic reticulum • membrane • cytoplasmic vesicle • endoplasmic reticulum-Golgi intermediate compartment • Golgi membrane • COPII-coated ER to Golgi transport vesicle • Golgi apparatus • intracellular membrane-bounded organelle Biological process • COPII vesicle coating • intracellular protein transport • Golgi organization • ER to Golgi vesicle-mediated transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	11196	207352
Ensembl	ENSG00000107651	ENSMUSG00000055319
UniProt	Q9Y6Y8	Q6NZC7
RefSeq (mRNA)	NM_007190	NM_001029982
RefSeq (protein)	NP_009121	n/a
Location (UCSC)	Chr 10: 119.89 – 119.94 Mb	Chr 7: 128.74 – 128.78 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

COPII-coated vesicles are involved in protein transport from the Endoplasmic Reticulum to the Golgi Apparatus. The protein encoded by this gene was identified by its interaction with a mouse protein similar to yeast Sec23p, an essential component of the COPII. This protein shares significant similarity with phospholipid-modifying proteins, especially phosphatidic acid preferring-phospholipase A1. Overexpression of this protein has been shown to cause disorganization of the endoplasmic reticulum-Golgi intermediate compartment and Golgi apparatus, which suggests its role in the early secretory pathway.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000107651 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000055319 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Tani K, Mizoguchi T, Iwamatsu A, Hatsuzawa K, Tagaya M (Aug 1999). "p125 is a novel mammalian Sec23p-interacting protein with structural similarity to phospholipid-modifying proteins". J Biol Chem. 274 (29): 20505–12. doi:10.1074/jbc.274.29.20505. PMID 10400679.
6. "Entrez Gene: SEC23IP SEC23 interacting protein".

Further reading

• Li H, Xie B, Zhou Y, et al. (2006). "Functional roles of p12, the fourth subunit of human DNA polymerase delta". J. Biol. Chem. 281 (21): 14748–55. doi:10.1074/jbc.M600322200. PMID 16510448.
• Shimoi W, Ezawa I, Nakamoto K, et al. (2005). "p125 is localized in endoplasmic reticulum exit sites and involved in their organization". J. Biol. Chem. 280 (11): 10141–8. doi:10.1074/jbc.M409673200. PMID 15623529.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Mizoguchi T, Nakajima K, Hatsuzawa K, et al. (2001). "Determination of functional regions of p125, a novel mammalian Sec23p-interacting protein". Biochem. Biophys. Res. Commun. 279 (1): 144–9. doi:10.1006/bbrc.2000.3846. PMID 11112430.