SFRS11

Splicing factor, arginine/serine-rich 11 is a protein that in humans is encoded by the SFRS11 gene.[5][6]

SRSF11
Identifiers
Aliases	SRSF11, NET2, SFRS11, dJ677H15.2, p54, serine/arginine-rich splicing factor 11, serine and arginine rich splicing factor 11
External IDs	OMIM: 602010 MGI: 1916457 HomoloGene: 36164 GeneCards: SRSF11
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p31.1 Start 70,205,682 bp[1] End 70,253,052 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 H4 Start 158,010,473 bp[2] End 158,036,639 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • nucleic acid binding • RNA binding Cellular component • cell nucleus • nucleoplasm • nuclear speck Biological process • mRNA splicing, via spliceosome • termination of RNA polymerase II transcription • mRNA processing • mRNA 3'-end processing • mRNA export from nucleus • RNA splicing • RNA export from nucleus Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9295	69207
Ensembl	ENSG00000116754	ENSMUSG00000055436
UniProt	Q05519 Q5T757	n/a
RefSeq (mRNA)	NM_001190987 NM_004768 NM_001350605 NM_001350606 NM_001350607 NM_001350608 NM_001350609 NM_001350610 NM_001350611 NM_001350612 NM_001350613 NM_001350614 NM_001350615 NM_001350616	NM_001093752 NM_001093753 NM_026989 NM_001356997
RefSeq (protein)	NP_001177916 NP_004759 NP_001337534 NP_001337535 NP_001337536 NP_001337537 NP_001337538 NP_001337539 NP_001337540 NP_001337541 NP_001337542 NP_001337543 NP_001337544 NP_001337545	n/a
Location (UCSC)	Chr 1: 70.21 – 70.25 Mb	Chr 3: 158.01 – 158.04 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes 54-kD nuclear protein that contains an arginine/serine-rich region similar to segments found in pre-mRNA splicing factors. Although the function of this protein is not yet known, structure and immunolocalization data suggest that it may play a role in pre-mRNA processing.[6]

Interactions

SFRS11 has been shown to interact with U2AF2.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000116754 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000055436 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Chaudhary N; McMahon C; Blobel G (October 1991). "Primary structure of a human arginine-rich nuclear protein that colocalizes with spliceosome components". Proc Natl Acad Sci U S A. 88 (18): 8189–93. Bibcode:1991PNAS...88.8189C. doi:10.1073/pnas.88.18.8189. PMC 52472. PMID 1896467.
6. "Entrez Gene: SFRS11 splicing factor, arginine/serine-rich 11".
7. Zhang, W J; Wu J Y (October 1996). "Functional properties of p54, a novel SR protein active in constitutive and alternative splicing". Mol. Cell. Biol. UNITED STATES. 16 (10): 5400–8. doi:10.1128/MCB.16.10.5400. ISSN 0270-7306. PMC 231539. PMID 8816452.

Further reading

• Zhang WJ; Wu JY (1996). "Functional properties of p54, a novel SR protein active in constitutive and alternative splicing". Mol. Cell. Biol. 16 (10): 5400–8. doi:10.1128/MCB.16.10.5400. PMC 231539. PMID 8816452.
• Straub T, Grue P, Uhse A, et al. (1998). "The RNA-splicing factor PSF/p54 controls DNA-topoisomerase I activity by a direct interaction". J. Biol. Chem. 273 (41): 26261–4. doi:10.1074/jbc.273.41.26261. PMID 9756848.
• Page-McCaw PS; Amonlirdviman K; Sharp PA (2000). "PUF60: a novel U2AF65-related splicing activity". RNA. 5 (12): 1548–60. doi:10.1017/S1355838299991938. PMC 1369877. PMID 10606266.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Sakashita E, Tatsumi S, Werner D, et al. (2004). "Human RNPS1 and its associated factors: a versatile alternative pre-mRNA splicing regulator in vivo". Mol. Cell. Biol. 24 (3): 1174–87. doi:10.1128/MCB.24.3.1174-1187.2004. PMC 321435. PMID 14729963.
• Wu JY, Kar A, Kuo D, et al. (2006). "SRp54 (SFRS11), a regulator for tau exon 10 alternative splicing identified by an expression cloning strategy". Mol. Cell. Biol. 26 (18): 6739–47. doi:10.1128/MCB.00739-06. PMC 1592875. PMID 16943417.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.