SHANK1

SH3 and multiple ankyrin repeat domains protein 1 is a protein that in humans is encoded by the SHANK1 gene.[5][6]

SHANK1
Identifiers
Aliases	SHANK1, SPANK-1, SSTRIP, synamon, SH3 and multiple ankyrin repeat domains 1
External IDs	OMIM: 604999 MGI: 3613677 HomoloGene: 22949 GeneCards: SHANK1
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.33 Start 50,661,827 bp[1] End 50,719,450 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 B3 Start 44,310,253 bp[2] End 44,360,572 bp[2]
Gene ontology Molecular function • somatostatin receptor binding • SH3 domain binding • ankyrin repeat binding • scaffold protein binding • protein C-terminus binding • GO:0001948 protein binding • GKAP/Homer scaffold activity • identical protein binding • ionotropic glutamate receptor binding • receptor signaling complex scaffold activity • GO:0032403 macromolecular complex binding Cellular component • cytoplasm • postsynaptic membrane • membrane • dendritic spine • synapse • excitatory synapse • intracellular • NMDA selective glutamate receptor complex • cell junction • dendrite • neuron projection • ionotropic glutamate receptor complex • GO:0097483, GO:0097481 postsynaptic density • cytosol • cell membrane • Schaffer collateral - CA1 synapse • glutamatergic synapse • neuron spine Biological process • cell differentiation • olfactory behavior • associative learning • neuromuscular process controlling balance • negative regulation of actin filament bundle assembly • positive regulation of dendritic spine development • nervous system development • regulation of AMPA receptor activity • dendritic spine morphogenesis • vocalization behavior • adult behavior • long-term memory • synapse maturation • positive regulation of excitatory postsynaptic potential • social organism behavior • habituation • determination of affect • righting reflex • protein localization to synapse • macromolecular complex assembly • postsynapse organization • synapse assembly • brain morphogenesis • synaptic growth at neuromuscular junction • positive regulation of synaptic transmission, glutamatergic • long-term synaptic potentiation • postsynaptic density assembly Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	50944	243961
Ensembl	ENSG00000161681	ENSMUSG00000038738
UniProt	Q9Y566	D3YZU1
RefSeq (mRNA)	NM_016148	NM_001034115
RefSeq (protein)	NP_057232	NP_001029287
Location (UCSC)	Chr 19: 50.66 – 50.72 Mb	Chr 7: 44.31 – 44.36 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

SHANK1 has been shown to interact with:

• ARHGEF7,[7]
• BAIAP2,[8]
• DNM2,[9]
• SPTAN1,[10] and
• Somatostatin receptor 2.[5]

References

1. GRCh38: Ensembl release 89: ENSG00000161681 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000038738 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Zitzer H, Hönck HH, Bächner D, Richter D, Kreienkamp HJ (January 2000). "Somatostatin receptor interacting protein defines a novel family of multidomain proteins present in human and rodent brain". J Biol Chem. 274 (46): 32997–3001. doi:10.1074/jbc.274.46.32997. PMID 10551867.
6. "Entrez Gene: SHANK1 SH3 and multiple ankyrin repeat domains 1".
7. Park E, Na M, Choi J, Kim S, Lee JR, Yoon J, Park D, Sheng M, Kim E (May 2003). "The Shank family of postsynaptic density proteins interacts with and promotes synaptic accumulation of the beta PIX guanine nucleotide exchange factor for Rac1 and Cdc42". J. Biol. Chem. 278 (21): 19220–9. doi:10.1074/jbc.M301052200. PMID 12626503.
8. Soltau M, Richter D, Kreienkamp HJ (Dec 2002). "The insulin receptor substrate IRSp53 links postsynaptic shank1 to the small G-protein cdc42". Mol. Cell. Neurosci. 21 (4): 575–83. doi:10.1006/mcne.2002.1201. PMID 12504591. S2CID 572407.
9. Okamoto PM, Gamby C, Wells D, Fallon J, Vallee RB (Dec 2001). "Dynamin isoform-specific interaction with the shank/ProSAP scaffolding proteins of the postsynaptic density and actin cytoskeleton". J. Biol. Chem. 276 (51): 48458–65. doi:10.1074/jbc.M104927200. PMC 2715172. PMID 11583995.
10. Böckers TM, Mameza MG, Kreutz MR, Bockmann J, Weise C, Buck F, Richter D, Gundelfinger ED, Kreienkamp HJ (October 2001). "Synaptic scaffolding proteins in rat brain. Ankyrin repeats of the multidomain Shank protein family interact with the cytoskeletal protein alpha-fodrin". J. Biol. Chem. 276 (43): 40104–12. doi:10.1074/jbc.M102454200. PMID 11509555.

Further reading

• Sheng M, Kim E (2000). "The Shank family of scaffold proteins". J. Cell Sci. 113 (11): 1851–6. PMID 10806096.
• Naisbitt S, Kim E, Tu JC, Xiao B, Sala C, Valtschanoff J, Weinberg RJ, Worley PF, Sheng M (1999). "Shank, a novel family of postsynaptic density proteins that binds to the NMDA receptor/PSD-95/GKAP complex and cortactin". Neuron. 23 (3): 569–82. doi:10.1016/S0896-6273(00)80809-0. PMID 10433268. S2CID 2209372.
• Tu JC, Xiao B, Naisbitt S, Yuan JP, Petralia RS, Brakeman P, Doan A, Aakalu VK, Lanahan AA, Sheng M, Worley PF (1999). "Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteins". Neuron. 23 (3): 583–92. doi:10.1016/S0896-6273(00)80810-7. PMID 10433269. S2CID 16429070.
• Tobaben S, Südhof TC, Stahl B (2000). "The G protein-coupled receptor CL1 interacts directly with proteins of the Shank family". J. Biol. Chem. 275 (46): 36204–10. doi:10.1074/jbc.M006448200. PMID 10958799.
• Kreienkamp HJ, Zitzer H, Gundelfinger ED, Richter D, Bockers TM (2000). "The calcium-independent receptor for alpha-latrotoxin from human and rodent brains interacts with members of the ProSAP/SSTRIP/Shank family of multidomain proteins". J. Biol. Chem. 275 (42): 32387–90. doi:10.1074/jbc.C000490200. PMID 10964907.
• Kreienkamp HJ, Zitzer H, Richter D (2001). "Identification of proteins interacting with the rat somatostatin receptor subtype 2". J. Physiol. Paris. 94 (3–4): 193–8. doi:10.1016/S0928-4257(00)00204-7. PMID 11087996. S2CID 8791865.
• Lim S, Sala C, Yoon J, Park S, Kuroda S, Sheng M, Kim E (2001). "Sharpin, a novel postsynaptic density protein that directly interacts with the shank family of proteins". Mol. Cell. Neurosci. 17 (2): 385–97. doi:10.1006/mcne.2000.0940. PMID 11178875. S2CID 45278068.
• Böckers TM, Mameza MG, Kreutz MR, Bockmann J, Weise C, Buck F, Richter D, Gundelfinger ED, Kreienkamp HJ (2001). "Synaptic scaffolding proteins in rat brain. Ankyrin repeats of the multidomain Shank protein family interact with the cytoskeletal protein alpha-fodrin". J. Biol. Chem. 276 (43): 40104–12. doi:10.1074/jbc.M102454200. PMID 11509555.
• Okamoto PM, Gamby C, Wells D, Fallon J, Vallee RB (2002). "Dynamin isoform-specific interaction with the shank/ProSAP scaffolding proteins of the postsynaptic density and actin cytoskeleton". J. Biol. Chem. 276 (51): 48458–65. doi:10.1074/jbc.M104927200. PMC 2715172. PMID 11583995.
• Soltau M, Richter D, Kreienkamp HJ (2003). "The insulin receptor substrate IRSp53 links postsynaptic shank1 to the small G-protein cdc42". Mol. Cell. Neurosci. 21 (4): 575–83. doi:10.1006/mcne.2002.1201. PMID 12504591. S2CID 572407.
• Park E, Na M, Choi J, Kim S, Lee JR, Yoon J, Park D, Sheng M, Kim E (2003). "The Shank family of postsynaptic density proteins interacts with and promotes synaptic accumulation of the beta PIX guanine nucleotide exchange factor for Rac1 and Cdc42". J. Biol. Chem. 278 (21): 19220–9. doi:10.1074/jbc.M301052200. PMID 12626503.
• Daigo Y, Takayama I, Ward SM, Sanders KM, Fujino MA (2004). "Novel human and mouse genes encoding a shank-interacting protein and its upregulation in gastric fundus of W/WV mouse". J. Gastroenterol. Hepatol. 18 (6): 712–8. doi:10.1046/j.1440-1746.2003.03046.x. PMID 12753155. S2CID 38146288.
• Im YJ, Lee JH, Park SH, Park SJ, Rho SH, Kang GB, Kim E, Eom SH (2004). "Crystal structure of the Shank PDZ-ligand complex reveals a class I PDZ interaction and a novel PDZ-PDZ dimerization". J. Biol. Chem. 278 (48): 48099–104. doi:10.1074/jbc.M306919200. PMID 12954649.
• Suzuki T, Li W, Zhang JP, Tian QB, Sakagami H, Usuda N, Usada N, Kondo H, Fujii T, Endo S (2005). "A novel scaffold protein, TANC, possibly a rat homolog of Drosophila rolling pebbles (rols), forms a multiprotein complex with various postsynaptic density proteins". Eur. J. Neurosci. 21 (2): 339–50. doi:10.1111/j.1460-9568.2005.03856.x. PMID 15673434. S2CID 28773407.
• Fieulaine S, Juillan-Binard C, Serero A, Dardel F, Giglione C, Meinnel T, Ferrer JL (2006). "The crystal structure of mitochondrial (Type 1A) peptide deformylase provides clear guidelines for the design of inhibitors specific for the bacterial forms". J. Biol. Chem. 280 (51): 42315–24. doi:10.1074/jbc.M507155200. PMID 16192279.