SHPRH

E3 ubiquitin-protein ligase SHPRH is an enzyme that in humans is encoded by the SHPRH gene.[5][6]

SHPRH
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2M85, 4QN1
Identifiers
Aliases	SHPRH, bA545I5.2, SNF2 histone linker PHD RING helicase
External IDs	OMIM: 608048 MGI: 1917581 HomoloGene: 6489 GeneCards: SHPRH
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q24.3 Start 145,864,245 bp[1] End 145,964,423 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 A1 Start 11,149,427 bp[2] End 11,217,595 bp[2]
Gene ontology Molecular function • DNA binding • nucleotide binding • GO:0001948 protein binding • hydrolase activity • ATP binding • GO:0008026 helicase activity • metal ion binding • ubiquitin-protein transferase activity • ubiquitin protein ligase binding • transferase activity • GO:1904264, GO:1904822, GO:0090622, GO:0090302 ubiquitin protein ligase activity Cellular component • nucleosome • cell nucleus • nucleoplasm Biological process • nucleosome assembly • protein polyubiquitination • DNA repair • cellular response to DNA damage stimulus • protein ubiquitination Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	257218	268281
Ensembl	ENSG00000146414	ENSMUSG00000090112
UniProt	Q149N8	Q7TPQ3
RefSeq (mRNA)	NM_001042683 NM_173082 NM_001370327 NM_001370328	NM_001077707 NM_001284354 NM_172937
RefSeq (protein)	NP_001036148 NP_775105 NP_001357256 NP_001357257	NP_001071175 NP_001271283 NP_766525
Location (UCSC)	Chr 6: 145.86 – 145.96 Mb	Chr 10: 11.15 – 11.22 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

SHPRH is a ubiquitously expressed protein that contains motifs characteristics of several DNA repair proteins, transcription factors, and helicases.[supplied by OMIM][6]

References

1. GRCh38: Ensembl release 89: ENSG00000146414 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000090112 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Sood R, Makalowska I, Galdzicki M, Hu P, Eddings E, Robbins CM, Moses T, Namkoong J, Chen S, Trent JM (August 2003). "Cloning and characterization of a novel gene, SHPRH, encoding a conserved putative protein with SNF2/helicase and PHD-finger domains from the 6q24 region". Genomics. 82 (2): 153–61. doi:10.1016/S0888-7543(03)00121-6. PMID 12837266.
6. "Entrez Gene: SHPRH SNF2 histone linker PHD RING helicase".

Further reading

• Motegi A, Sood R, Moinova H, Markowitz SD, Liu PP, Myung K (December 2006). "Human SHPRH suppresses genomic instability through proliferating cell nuclear antigen polyubiquitination". The Journal of Cell Biology. 175 (5): 703–8. doi:10.1083/jcb.200606145. PMC 2064669. PMID 17130289.
• Unk I, Hajdú I, Fátyol K, Szakál B, Blastyák A, Bermudez V, Hurwitz J, Prakash L, Prakash S, Haracska L (November 2006). "Human SHPRH is a ubiquitin ligase for Mms2-Ubc13-dependent polyubiquitylation of proliferating cell nuclear antigen". Proceedings of the National Academy of Sciences of the United States of America. 103 (48): 18107–12. Bibcode:2006PNAS..10318107U. doi:10.1073/pnas.0608595103. PMC 1838714. PMID 17108083.
• Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T (August 2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization" (PDF). Current Biology. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660. S2CID 2371325.
• Adams MD, Kerlavage AR, Fleischmann RD, Fuldner RA, Bult CJ, Lee NH, Kirkness EF, Weinstock KG, Gocayne JD, White O (September 1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence" (PDF). Nature. 377 (6547 Suppl): 3–174. PMID 7566098.