SLFN14

Schlafen family member 14 is a protein that in humans is encoded by the SLFN14 gene. [5]

SLFN14
Identifiers
Aliases	SLFN14, BDPLT20, schlafen family member 14
External IDs	OMIM: 614958 MGI: 2684866 HomoloGene: 19082 GeneCards: SLFN14
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q12 Start 35,548,125 bp[1] End 35,558,098 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 C Start 83,275,110 bp[2] End 83,286,726 bp[2]
Gene ontology Molecular function • ribosome binding • ATP binding • endoribonuclease activity • nuclease activity • hydrolase activity • endonuclease activity • nucleotide binding Cellular component • cytoplasm • cell nucleus Biological process • rRNA catabolic process • cellular response to magnesium ion • cellular response to manganese ion • mRNA catabolic process • RNA phosphodiester bond hydrolysis, endonucleolytic • platelet maturation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	342618	237890
Ensembl	ENSG00000236320	ENSMUSG00000082101
UniProt	P0C7P3	V9GXG1
RefSeq (mRNA)	NM_001129820	NM_001166028
RefSeq (protein)	NP_001123292	NP_001159500
Location (UCSC)	Chr 17: 35.55 – 35.56 Mb	Chr 11: 83.28 – 83.29 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The protein encoded by this gene plays an important role in platelet formation and function. Defects in this gene are a cause of thrombocytopenia with excessive bleeding. [provided by RefSeq, Jul 2016].

References

1. GRCh38: Ensembl release 89: ENSG00000236320 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000082101 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Schlafen family member 14". Retrieved 2020-04-11.

Further reading

• Fletcher SJ, Johnson B, Lowe GC, Bem D, Drake S, Lordkipanidzé M, Guiú IS, Dawood B, Rivera J, Simpson MA, Daly ME, Motwani J, Collins PW, Watson SP, Morgan NV (September 2015). "SLFN14 mutations underlie thrombocytopenia with excessive bleeding and platelet secretion defects". J. Clin. Invest. 125 (9): 3600–5. doi:10.1172/JCI80347. PMC 4588283. PMID 26280575.
• Marconi C, Di Buduo CA, Barozzi S, Palombo F, Pardini S, Zaninetti C, Pippucci T, Noris P, Balduini A, Seri M, Pecci A (May 2016). "SLFN14-related thrombocytopenia: identification within a large series of patients with inherited thrombocytopenia". Thromb. Haemost. 115 (5): 1076–9. doi:10.1160/TH15-11-0884. PMID 26769223.
• Seong RK, Seo SW, Kim JA, Fletcher SJ, Morgan NV, Kumar M, Choi YK, Shin OS (November 2017). "Schlafen 14 (SLFN14) is a novel antiviral factor involved in the control of viral replication". Immunobiology. 222 (11): 979–988. doi:10.1016/j.imbio.2017.07.002. PMC 5990420. PMID 28734654.
• Fletcher SJ, Pisareva VP, Khan AO, Tcherepanov A, Morgan NV, Pisarev AV (July 2018). "Role of the novel endoribonuclease SLFN14 and its disease-causing mutations in ribosomal degradation". RNA. 24 (7): 939–949. doi:10.1261/rna.066415.118. PMC 6004054. PMID 29678925.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.