SLFN5

Schlafen family member 5 is a protein that in humans is encoded by the SLFN5 gene. [5]

SLFN5
Identifiers
Aliases	SLFN5, schlafen family member 5
External IDs	OMIM: 614952 MGI: 1329004 HomoloGene: 18839 GeneCards: SLFN5
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q12 Start 35,243,071 bp[1] End 35,273,655 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 C Start 82,951,349 bp[2] End 82,964,840 bp[2]
Gene ontology Molecular function • ATP binding • nucleotide binding Cellular component • cell nucleus Biological process • cell differentiation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	162394	327978
Ensembl	ENSG00000166750	ENSMUSG00000054404
UniProt	Q08AF3	Q8CBA2
RefSeq (mRNA)	NM_144975 NM_001330183	NM_183201
RefSeq (protein)	NP_001317112 NP_659412	NP_899024
Location (UCSC)	Chr 17: 35.24 – 35.27 Mb	Chr 11: 82.95 – 82.96 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000166750 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000054404 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Schlafen family member 5". Retrieved 2020-04-11.

Further reading

• Katsoulidis E, Mavrommatis E, Woodard J, Shields MA, Sassano A, Carayol N, Sawicki KT, Munshi HG, Platanias LC (December 2010). "Role of interferon {alpha} (IFN{alpha})-inducible Schlafen-5 in regulation of anchorage-independent growth and invasion of malignant melanoma cells". J. Biol. Chem. 285 (51): 40333–41. doi:10.1074/jbc.M110.151076. PMC 3001013. PMID 20956525.
• Sassano A, Mavrommatis E, Arslan AD, Kroczynska B, Beauchamp EM, Khuon S, Chew TL, Green KJ, Munshi HG, Verma AK, Platanias LC (August 2015). "Human Schlafen 5 (SLFN5) Is a Regulator of Motility and Invasiveness of Renal Cell Carcinoma Cells". Mol. Cell. Biol. 35 (15): 2684–98. doi:10.1128/MCB.00019-15. PMC 4524119. PMID 26012550.
• Companioni Nápoles O, Tsao AC, Sanz-Anquela JM, Sala N, Bonet C, Pardo ML, Ding L, Simo O, Saqui-Salces M, Blanco VP, Gonzalez CA, Merchant JL (January 2017). "SCHLAFEN 5 expression correlates with intestinal metaplasia that progresses to gastric cancer". J. Gastroenterol. 52 (1): 39–49. doi:10.1007/s00535-016-1202-4. PMC 5045746. PMID 27032393.
• Arslan AD, Sassano A, Saleiro D, Lisowski P, Kosciuczuk EM, Fischietti M, Eckerdt F, Fish EN, Platanias LC (October 2017). "Human SLFN5 is a transcriptional co-repressor of STAT1-mediated interferon responses and promotes the malignant phenotype in glioblastoma". Oncogene. 36 (43): 6006–6019. doi:10.1038/onc.2017.205. PMC 5821504. PMID 28671669.