SLITRK5

SLIT and NTRK-like protein 5 is a protein that in humans is encoded by the SLITRK5 gene.[5][6][7]

SLITRK5
Identifiers
Aliases	SLITRK5, LRRC11, bA364G4.2, SLIT and NTRK like family member 5
External IDs	OMIM: 609680 MGI: 2679448 HomoloGene: 9193 GeneCards: SLITRK5
Gene location (Human) Chr. Chromosome 13 (human)[1] Band 13q31.2 Start 87,672,615 bp[1] End 87,696,272 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 E4 Start 111,675,097 bp[2] End 111,683,141 bp[2]
RNA expression pattern More reference expression data
Orthologs
Species	Human	Mouse
Entrez	26050	75409
Ensembl	ENSG00000165300	ENSMUSG00000033214
UniProt	O94991	Q810B7
RefSeq (mRNA)	NM_015567	NM_029273 NM_198865 NM_001378768 NM_001378769 NM_001378770
RefSeq (protein)	NP_056382	NP_942565 NP_001365697 NP_001365698 NP_001365699
Location (UCSC)	Chr 13: 87.67 – 87.7 Mb	Chr 14: 111.68 – 111.68 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

Members of the SLITRK family, such as SLITRK5, are integral membrane proteins with 2 N-terminal leucine-rich repeat (LRR) domains similar to those of SLIT proteins (see SLIT1; MIM 603742). Most SLITRKs, including SLITRK5, also have C-terminal regions that share homology with neurotrophin receptors (see NTRK1; MIM 191315). SLITRKs are expressed predominantly in neural tissues and have neurite-modulating activity (Aruga et al., 2003).[supplied by OMIM][7]

References

1. GRCh38: Ensembl release 89: ENSG00000165300 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000033214 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (December 1998). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.
6. Aruga J, Yokota N, Mikoshiba K (October 2003). "Human SLITRK family genes: genomic organization and expression profiling in normal brain and brain tumor tissue". Gene. 315: 87–94. doi:10.1016/S0378-1119(03)00715-7. PMID 14557068.
7. "Entrez Gene: SLITRK5 SLIT and NTRK-like family, member 5".

Further reading

• Amanchy R, Kalume DE, Iwahori A, Zhong J, Pandey A (2006). "Phosphoproteome analysis of HeLa cells using stable isotope labeling with amino acids in cell culture (SILAC)". Journal of Proteome Research. 4 (5): 1661–71. doi:10.1021/pr050134h. PMID 16212419.
• Aruga J, Mikoshiba K (September 2003). "Identification and characterization of Slitrk, a novel neuronal transmembrane protein family controlling neurite outgrowth". Molecular and Cellular Neurosciences. 24 (1): 117–29. doi:10.1016/S1044-7431(03)00129-5. PMID 14550773.