SLK (gene)

STE20-like serine/threonine-protein kinase is an enzyme that in humans is encoded by the SLK gene.[5][6]

SLK
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2J51, 2JFL, 2JFM, 2UV2, 4USF
Identifiers
Aliases	SLK, LOSK, STK2, bA16H23.1, se20-9, STE20 like kinase
External IDs	OMIM: 616563 MGI: 103241 HomoloGene: 22515 GeneCards: SLK
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q24.33-q25.1 Start 103,967,140 bp[1] End 104,029,233 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 C3-D1 Start 47,579,678 bp[2] End 47,645,246 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • transferase activity • nucleotide binding • protein kinase activity • protein homodimerization activity • kinase activity • protein serine/threonine kinase activity • GO:0001948 protein binding • identical protein binding • ATP binding • cadherin binding Cellular component • extracellular exosome • cell leading edge • perinuclear region of cytoplasm • cytoplasm Biological process • phosphorylation • protein phosphorylation • cytoplasmic microtubule organization • regulation of focal adhesion assembly • autophosphorylation • apoptotic process • regulation of cell migration • regulation of apoptotic process • regulation of mitotic cell cycle • signal transduction by protein phosphorylation • stress-activated protein kinase signaling cascade • activation of protein kinase activity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9748	20874
Ensembl	ENSG00000065613	ENSMUSG00000025060
UniProt	Q9H2G2	O54988
RefSeq (mRNA)	NM_001304743 NM_014720	NM_001164639 NM_009289
RefSeq (protein)	NP_001291672 NP_055535	NP_001158111 NP_033315
Location (UCSC)	Chr 10: 103.97 – 104.03 Mb	Chr 19: 47.58 – 47.65 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

SLK (gene) has been shown to interact with PDZK1.[7]

SLK is a mammalian gene located on chromosome 10. it has also been cloned in rats.[8] There is a whole family of STE20 like protein kinases, which has been divided into three categories. the most important p21-activated kinase (PAK), germinal center kinases (GCK) and Pleckstrin homology domain containing PAK (PHPAK).[9] SLK gene plays an important role in development, termination and differentiation of cells and tissues. the main enzyme SLK gene produces is called Ste20-like kinases which was formerly known as Ste20-like serine/threonine protein kinase. the balanced expression of SLK gene is very essential for the correct development of body parts in all mammals. this enzyme is also involved in cell movement and cell cycle. The expression of SLK gene in germ line cell is regulated by phosphorylation of PLK1, which is another gene involved in mitosis. Ste20- like kinases manages the correct orientation of micro-tubules during inter-phase level of cell cycles. Underproduction of Ste20-like serine/threonine-protein kinases can result in micro-tubule fibers to detach from chromosomes. It also functions in activation/deactivation of apoptosis in cells, as well as organization and adhesion of cell to shape an appropriate organ.

[10][11]

References

1. GRCh38: Ensembl release 89: ENSG00000065613 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000025060 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Celenza JL, Carlson M (Sep 1986). "A yeast gene that is essential for release from glucose repression encodes a protein kinase". Science. 233 (4769): 1175–80. Bibcode:1986Sci...233.1175C. doi:10.1126/science.3526554. PMID 3526554.
6. "Entrez Gene: SLK STE20-like kinase (yeast)".
7. Gisler SM, Pribanic S, Bacic D, Forrer P, Gantenbein A, Sabourin LA, Tsuji A, Zhao ZS, Manser E, Biber J, Murer H (Nov 2003). "PDZK1: I. a major scaffolder in brush borders of proximal tubular cells". Kidney International. 64 (5): 1733–45. doi:10.1046/j.1523-1755.2003.00266.x. PMID 14531806.
8. Ste20-like kinases SLK, at the crossroad
9. Al‐Zahrani, Sekhon. “Essential Role for the SLK Protein Kinase in Embryogenesis and Placental Tissue Development.” Developmental Dynamics, vol. 243, no. 5, Wiley Subscription Services, Inc, May 2014, pp. 640–51, doi:10.1002/dvdy.24106
10. Cybulsky, Papillon. “Ste20-Like Kinase, SLK, a Novel Mediator of Podocyte Integrity.” American Journal of Physiology. Renal Physiology, vol. 315, no. 1, American Physiological Society, July 2018, pp. F186–F198, doi:10.1152/ajprenal.00238.2017
11. Cybulsky, Takano. “The Ste20-Like Kinase SLK Promotes P53 Transactivation and Apoptosis.” American Journal of Physiology. Renal Physiology 297.4 (2009): 971–980. Web

Further reading

• Yan Y, Nguyen H, Dalmasso G, Sitaraman SV, Merlin D (Feb 2007). "Cloning and characterization of a new intestinal inflammation-associated colonic epithelial Ste20-related protein kinase isoform". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1769 (2): 106–16. doi:10.1016/j.bbaexp.2007.01.003. PMC 1865517. PMID 17321610.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
• Chaar Z, O'reilly P, Gelman I, Sabourin LA (Sep 2006). "v-Src-dependent down-regulation of the Ste20-like kinase SLK by casein kinase II". The Journal of Biological Chemistry. 281 (38): 28193–9. doi:10.1074/jbc.M605665200. PMID 16837460.
• Gisler SM, Pribanic S, Bacic D, Forrer P, Gantenbein A, Sabourin LA, Tsuji A, Zhao ZS, Manser E, Biber J, Murer H (Nov 2003). "PDZK1: I. a major scaffolder in brush borders of proximal tubular cells". Kidney International. 64 (5): 1733–45. doi:10.1046/j.1523-1755.2003.00266.x. PMID 14531806.
• Nakayama M, Kikuno R, Ohara O (Nov 2002). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Research. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765.
• Dan I, Watanabe NM, Kusumi A (May 2001). "The Ste20 group kinases as regulators of MAP kinase cascades". Trends in Cell Biology. 11 (5): 220–30. doi:10.1016/S0962-8924(01)01980-8. PMID 11316611.
• Eichmuller S, Usener D, Dummer R, Stein A, Thiel D, Schadendorf D (Jan 2001). "Serological detection of cutaneous T-cell lymphoma-associated antigens". Proceedings of the National Academy of Sciences of the United States of America. 98 (2): 629–34. doi:10.1073/pnas.021386498. PMC 14639. PMID 11149944.
• Yamada E, Tsujikawa K, Itoh S, Kameda Y, Kohama Y, Yamamoto H (Feb 2000). "Molecular cloning and characterization of a novel human STE20-like kinase, hSLK". Biochimica et Biophysica Acta. 1495 (3): 250–62. doi:10.1016/S0167-4889(99)00164-0. PMID 10699464.
• Sabourin LA, Tamai K, Seale P, Wagner J, Rudnicki MA (Jan 2000). "Caspase 3 cleavage of the Ste20-related kinase SLK releases and activates an apoptosis-inducing kinase domain and an actin-disassembling region". Molecular and Cellular Biology. 20 (2): 684–96. doi:10.1128/MCB.20.2.684-696.2000. PMC 85169. PMID 10611247.
• Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, Tanaka A, Kotani H, Miyajima N, Nomura N (Oct 1996). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Research. 3 (5): 321–9, 341–54. doi:10.1093/dnares/3.5.321. PMID 9039502.