SLU7

Pre-mRNA-splicing factor SLU7 is a protein that in humans is encoded by the SLU7 gene.[5][6][7]

SLU7
Identifiers
Aliases	SLU7, 9G8, hSlu7, SLU7 homolog, splicing factor
External IDs	OMIM: 605974 MGI: 2385598 HomoloGene: 4690 GeneCards: SLU7
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q33.3 Start 160,401,641 bp[1] End 160,421,711 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 B1.1 Start 43,433,744 bp[2] End 43,447,981 bp[2]
Gene ontology Molecular function • pre-mRNA 3'-splice site binding • second spliceosomal transesterification activity • metal ion binding • GO:0001948 protein binding • nucleic acid binding • zinc ion binding Cellular component • cytoplasm • nuclear speck • catalytic step 2 spliceosome • membrane • intracellular membrane-bounded organelle • small nuclear ribonucleoprotein complex • spliceosomal complex • cell nucleus • nucleoplasm • cytosol Biological process • cellular response to heat • RNA splicing, via transesterification reactions • mRNA processing • mRNA 3'-splice site recognition • RNA splicing • intracellular protein transport • alternative mRNA splicing, via spliceosome • RNA export from nucleus • mRNA splicing, via spliceosome • mRNA export from nucleus • mRNA 3'-end processing • termination of RNA polymerase II transcription Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10569	193116
Ensembl	ENSG00000164609	ENSMUSG00000020409
UniProt	O95391	Q8BHJ9
RefSeq (mRNA)	NM_006425	NM_148673 NM_198936
RefSeq (protein)	NP_006416 NP_001351446 NP_001351447 NP_001351449 NP_001351450 NP_001351451 NP_001351452	NP_683514 NP_945174
Location (UCSC)	Chr 5: 160.4 – 160.42 Mb	Chr 11: 43.43 – 43.45 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Pre-mRNA splicing occurs in two sequential transesterification steps. The protein encoded by this gene is a splicing factor that has been found to be essential during the second catalytic step in the pre-mRNA splicing process. It associates with the spliceosome and contains a zinc knuckle motif that is found in other splicing factors and is involved in protein-nucleic acid and protein-protein interactions.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000164609 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020409 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Chua K, Reed R (May 1999). "Human step II splicing factor hSlu7 functions in restructuring the spliceosome between the catalytic steps of splicing". Genes Dev. 13 (7): 841–50. doi:10.1101/gad.13.7.841. PMC 316594. PMID 10197984.
6. Shomron N, Alberstein M, Reznik M, Ast G (Mar 2005). "Stress alters the subcellular distribution of hSlu7 and thus modulates alternative splicing". J Cell Sci. 118 (Pt 6): 1151–9. doi:10.1242/jcs.01720. PMID 15728250.
7. "Entrez Gene: SLU7 SLU7 splicing factor homolog (S. cerevisiae)".

Further reading

• Alberstein M, Amit M, Vaknin K, et al. (2008). "Regulation of transcription of the RNA splicing factor hSlu7 by Elk-1 and Sp1 affects alternative splicing". RNA. 13 (11): 1988–99. doi:10.1261/rna.492907. PMC 2040095. PMID 17804646.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Shomron N, Reznik M, Ast G (2005). "Splicing factor hSlu7 contains a unique functional domain required to retain the protein within the nucleus". Mol. Biol. Cell. 15 (8): 3782–95. doi:10.1091/mbc.E04-02-0152. PMC 491837. PMID 15181151.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Chua K, Reed R (2001). "An upstream AG determines whether a downstream AG is selected during catalytic step II of splicing". Mol. Cell. Biol. 21 (5): 1509–14. doi:10.1128/MCB.21.5.1509-1514.2001. PMC 86697. PMID 11238888.
• Chua K, Reed R (2000). "The RNA splicing factor hSlu7 is required for correct 3' splice-site choice". Nature. 402 (6758): 207–10. doi:10.1038/46086. PMID 10647016. S2CID 4428185.