SMARCD2

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 is a protein that in humans is encoded by the SMARCD2 gene.[5][6][7]

SMARCD2
Identifiers
Aliases	SMARCD2, BAF60B, CRACD2, Rsc6p, PRO2451, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2, SGD2
External IDs	OMIM: 601736 MGI: 1933621 HomoloGene: 20671 GeneCards: SMARCD2
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q23.3 Start 63,832,081 bp[1] End 63,843,065 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 E1 Start 106,263,179 bp[2] End 106,272,972 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • nucleosomal DNA binding • GO:0001105 transcription coactivator activity • GO:0001948 protein binding Cellular component • nuclear chromatin • SWI/SNF complex • cell nucleus • nucleoplasm • macromolecular complex Biological process • regulation of transcription from RNA polymerase II promoter • chromatin remodeling • nucleosome disassembly • regulation of transcription, DNA-templated • transcription, DNA-templated • ATP-dependent chromatin remodeling • covalent chromatin modification • chromatin organization • positive regulation of nucleic acid-templated transcription Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6603	83796
Ensembl	ENSG00000108604	ENSMUSG00000078619
UniProt	Q92925	Q99JR8
RefSeq (mRNA)	NM_001098426 NM_003077 NM_001330439 NM_001330440	NM_001130187 NM_031878
RefSeq (protein)	NP_001091896 NP_001317368 NP_001317369	NP_001123659 NP_114084
Location (UCSC)	Chr 17: 63.83 – 63.84 Mb	Chr 11: 106.26 – 106.27 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and has sequence similarity to the yeast Swp73 protein.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000108604 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000078619 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Wang W, Xue Y, Zhou S, Kuo A, Cairns BR, Crabtree GR (Nov 1996). "Diversity and specialization of mammalian SWI/SNF complexes". Genes Dev. 10 (17): 2117–30. doi:10.1101/gad.10.17.2117. PMID 8804307.
6. Ring HZ, Vameghi-Meyers V, Wang W, Crabtree GR, Francke U (Sep 1998). "Five SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin (SMARC) genes are dispersed in the human genome". Genomics. 51 (1): 140–3. doi:10.1006/geno.1998.5343. PMID 9693044.
7. "Entrez Gene: SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2".

Further reading

• Wang W, Côté J, Xue Y, et al. (1996). "Purification and biochemical heterogeneity of the mammalian SWI-SNF complex". EMBO J. 15 (19): 5370–82. doi:10.1002/j.1460-2075.1996.tb00921.x. PMC 452280. PMID 8895581.
• Surabhi RM, Daly LD, Cattini PA (1999). "Evidence for evolutionary conservation of a physical linkage between the human BAF60b, a subunit of SWI/SNF complex, and thyroid hormone receptor interacting protein-1 genes on chromosome 17". Genome. 42 (3): 545–9. doi:10.1139/gen-42-3-545. PMID 10382302.
• Bochar DA, Wang L, Beniya H, et al. (2000). "BRCA1 is associated with a human SWI/SNF-related complex: linking chromatin remodeling to breast cancer". Cell. 102 (2): 257–65. doi:10.1016/S0092-8674(00)00030-1. PMID 10943845. S2CID 6500100.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Nie Z, Yan Z, Chen EH, et al. (2003). "Novel SWI/SNF chromatin-remodeling complexes contain a mixed-lineage leukemia chromosomal translocation partner". Mol. Cell. Biol. 23 (8): 2942–52. doi:10.1128/MCB.23.8.2942-2952.2003. PMC 152562. PMID 12665591.
• Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.