SMCP

Sperm mitochondrial-associated cysteine-rich protein is a protein that in humans is encoded by the SMCP gene.[3][4]

SMCP
Identifiers
Aliases	SMCP, HSMCSGEN1, MCS, MCSP, sperm mitochondria associated cysteine rich protein
External IDs	OMIM: 601148 HomoloGene: 136205 GeneCards: SMCP
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q21.3 Start 152,878,322 bp[1] End 152,885,047 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • molecular function Cellular component • cytoplasm • mitochondrial membranes • mitochondrion • membrane Biological process • flagellated sperm motility • penetration of zona pellucida • single fertilization Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4184	n/a
Ensembl	ENSG00000163206	n/a
UniProt	P49901	n/a
RefSeq (mRNA)	NM_030663	n/a
RefSeq (protein)	NP_109588	n/a
Location (UCSC)	Chr 1: 152.88 – 152.89 Mb	n/a
PubMed search	[2]	n/a
Wikidata
View/Edit Human

Function

Sperm mitochondria differ in morphology and subcellular localization from those of somatic cells. They are elongated, flattened, and arranged circumferentially to form a helical coiled sheath in the midpiece of the sperm flagellum. The protein encoded by this gene localizes to the capsule associated with the mitochondrial outer membranes and is thought to function in the organization and stabilization of the helical structure of the sperm's mitochondrial sheath.[4]

References

1. GRCh38: Ensembl release 89: ENSG00000163206 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Aho H, Schwemmer M, Tessman D, Murphy D, Mattei G, Engel W, Adham IM (Mar 1996). "Isolation, expression, and chromosomal localization of the human mitochondrial capsule selenoprotein gene (MCSP)". Genomics. 32 (2): 184–90. doi:10.1006/geno.1996.0104. PMID 8833144.
4. "Entrez Gene: SMCP sperm mitochondria-associated cysteine-rich protein".

Further reading

• Behne D, Kyriakopoulos A (2001). "Mammalian selenium-containing proteins". Annual Review of Nutrition. 21: 453–73. doi:10.1146/annurev.nutr.21.1.453. PMID 11375445.
• Karimpour I, Cutler M, Shih D, Smith J, Kleene KC (Nov 1992). "Sequence of the gene encoding the mitochondrial capsule selenoprotein of mouse sperm: identification of three in-phase TGA selenocysteine codons". DNA and Cell Biology. 11 (9): 693–9. doi:10.1089/dna.1992.11.693. PMID 1418626.
• Saaranen M, Suistomaa U, Vanha-Perttula T (Apr 1989). "Semen selenium content and sperm mitochondrial volume in human and some animal species". Human Reproduction. 4 (3): 304–8. doi:10.1093/oxfordjournals.humrep.a136893. PMID 2715306.
• Cataldo L, Baig K, Oko R, Mastrangelo MA, Kleene KC (Nov 1996). "Developmental expression, intracellular localization, and selenium content of the cysteine-rich protein associated with the mitochondrial capsules of mouse sperm". Molecular Reproduction and Development. 45 (3): 320–31. doi:10.1002/(SICI)1098-2795(199611)45:3<320::AID-MRD9>3.0.CO;2-U. PMID 8916043.
• Herr JC, Thomas D, Bush LA, Coonrod S, Khole V, Howards SS, Flickinger CJ (Aug 1999). "Sperm mitochondria-associated cysteine-rich protein (SMCP) is an autoantigen in Lewis rats". Biology of Reproduction. 61 (2): 428–35. doi:10.1095/biolreprod61.2.428. PMID 10411523.
• Nayernia K, Adham IM, Burkhardt-Göttges E, Neesen J, Rieche M, Wolf S, Sancken U, Kleene K, Engel W (May 2002). "Asthenozoospermia in mice with targeted deletion of the sperm mitochondrion-associated cysteine-rich protein (Smcp) gene". Molecular and Cellular Biology. 22 (9): 3046–52. doi:10.1128/MCB.22.9.3046-3052.2002. PMC 133774. PMID 11940662.
• Hawthorne SK, Goodarzi G, Bagarova J, Gallant KE, Busanelli RR, Olend WJ, Kleene KC (Mar 2006). "Comparative genomics of the sperm mitochondria-associated cysteine-rich protein gene". Genomics. 87 (3): 382–91. doi:10.1016/j.ygeno.2005.09.010. PMID 16325371.
• Yatsenko AN, Roy A, Chen R, Ma L, Murthy LJ, Yan W, Lamb DJ, Matzuk MM (Dec 2006). "Non-invasive genetic diagnosis of male infertility using spermatozoal RNA: KLHL10 mutations in oligozoospermic patients impair homodimerization". Human Molecular Genetics. 15 (23): 3411–9. doi:10.1093/hmg/ddl417. PMID 17047026.