SMIM20

Small integral membrane protein (SMIM) 20 is a protein that in humans is encoded by the SMIM20 gene.[4] SMIM20 acts as a prohormone to the peptide hormone phoenixin which was discovered for the first time in 2013 in rodent sensory ganglia.[5]

SMIM20
Identifiers
Aliases	SMIM20, C4orf52, small integral membrane protein 20, MITRAC7, PNX
External IDs	OMIM: 617465 MGI: 1913528 HomoloGene: 82612 GeneCards: SMIM20
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4p15.2 Start 25,861,830 bp[1] End 25,929,874 bp[1]
Gene ontology Molecular function • GO:0001948 protein binding Cellular component • membrane • integral component of membrane • mitochondrion • mitochondrial inner membrane Biological process • mitochondrial respiratory chain complex IV assembly Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	389203	66278
Ensembl	ENSG00000250317	ENSMUSG00000061461
UniProt	Q8N5G0	D3Z7Q2
RefSeq (mRNA)	NM_001145432	NM_001145433
RefSeq (protein)	NP_001138904	NP_001138905
Location (UCSC)	Chr 4: 25.86 – 25.93 Mb	n/a
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000250317 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Entrez Gene: Small integral membrane protein 20". Retrieved 2014-02-05.
5. Neuroscience. 2013 Oct 10;250:622-31. doi: 10.1016 Yosten, G. L., Lyu, R. M., Hsueh, A. J., Avsian‐Kretchmer, O., Chang, J. K., Tullock, C. W., ... & Samson, W. K. (2013). A novel reproductive peptide, phoenixin. Journal of neuroendocrinology, 25(2), 206-215.

Further reading