SMPD3

Sphingomyelin phosphodiesterase 3 is an enzyme that in humans is encoded by the SMPD3 gene.[5][6]

SMPD3
Identifiers
Aliases	SMPD3, NSMASE2, sphingomyelin phosphodiesterase 3
External IDs	OMIM: 605777 MGI: 1927578 HomoloGene: 10260 GeneCards: SMPD3
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16q22.1 Start 68,358,327 bp[1] End 68,448,508 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 D3 Start 106,252,548 bp[2] End 106,337,988 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • sphingomyelin phosphodiesterase activity • metal ion binding • hydrolase activity • GO:0001948 protein binding • neutral sphingomyelin phosphodiesterase activity • phospholipase activity Cellular component • Golgi apparatus • membrane • Golgi membrane • Golgi cis cisterna • cell membrane • cytoplasm Biological process • positive regulation of ceramide biosynthetic process • lipid metabolism • multicellular organism development • sphingomyelin catabolic process • peptide hormone secretion • hematopoietic progenitor cell differentiation • cell cycle • positive regulation of exosomal secretion • sphingomyelin metabolic process • sphingolipid metabolic process • skeletal system development • endochondral ossification • chondrocyte development • regulation of leukocyte migration • bone mineralization • BMP signaling pathway • multicellular organism growth • protein kinase B signaling • cartilage development • protein homooligomerization • bone development • regulation of cartilage development • cellular response to redox state • bone growth • cellular response to peptide • ossification • regulation of protein phosphorylation • chondrocyte development involved in endochondral bone morphogenesis • ceramide metabolic process • glycosphingolipid metabolic process • signal transduction • polysaccharide transport • lung development • collagen metabolic process • cellular response to reactive oxygen species • positive regulation of mitotic nuclear division • platelet-derived growth factor receptor signaling pathway • lung alveolus development • positive regulation of smooth muscle cell proliferation • respiratory system development • cellular response to hydrogen peroxide • G1 to G0 transition • cellular response to magnesium ion • cellular response to tumor necrosis factor • DNA biosynthetic process • extracellular matrix assembly • sphingolipid mediated signaling pathway • dentinogenesis • mitotic nuclear division • cellular response to oxidised low-density lipoprotein particle stimulus • regulation of hyaluronan biosynthetic process • negative regulation of hyaluronan biosynthetic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	55512	58994
Ensembl	ENSG00000103056	ENSMUSG00000031906
UniProt	Q9NY59	Q9JJY3
RefSeq (mRNA)	NM_018667	NM_021491
RefSeq (protein)	NP_061137	NP_067466
Location (UCSC)	Chr 16: 68.36 – 68.45 Mb	Chr 8: 106.25 – 106.34 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000103056 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000031906 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Hofmann K, Tomiuk S, Wolff G, Stoffel W (Jun 2000). "Cloning and characterization of the mammalian brain-specific, Mg2+-dependent neutral sphingomyelinase". Proc Natl Acad Sci U S A. 97 (11): 5895–900. doi:10.1073/pnas.97.11.5895. PMC 18530. PMID 10823942.
6. "Entrez Gene: SMPD3 sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)".

Further reading

• Chagnon P, Michaud J, Mitchell G, et al. (2003). "A missense mutation (R565W) in cirhin (FLJ14728) in North American Indian childhood cirrhosis". Am. J. Hum. Genet. 71 (6): 1443–9. doi:10.1086/344580. PMC 378590. PMID 12417987.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Marchesini N, Luberto C, Hannun YA (2003). "Biochemical properties of mammalian neutral sphingomyelinase 2 and its role in sphingolipid metabolism". J. Biol. Chem. 278 (16): 13775–83. doi:10.1074/jbc.M212262200. PMID 12566438.
• Miura Y, Gotoh E, Nara F, et al. (2004). "Hydrolysis of sphingosylphosphocholine by neutral sphingomyelinases". FEBS Lett. 557 (1–3): 288–92. doi:10.1016/S0014-5793(03)01523-0. PMID 14741383. S2CID 34738077.
• Marchesini N, Osta W, Bielawski J, et al. (2004). "Role for mammalian neutral sphingomyelinase 2 in confluence-induced growth arrest of MCF7 cells". J. Biol. Chem. 279 (24): 25101–11. doi:10.1074/jbc.M313662200. PMID 15051724.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Jana A, Pahan K (2005). "Human immunodeficiency virus type 1 gp120 induces apoptosis in human primary neurons through redox-regulated activation of neutral sphingomyelinase". J. Neurosci. 24 (43): 9531–40. doi:10.1523/JNEUROSCI.3085-04.2004. PMC 1955476. PMID 15509740.
• Krut O, Wiegmann K, Kashkar H, et al. (2006). "Novel tumor necrosis factor-responsive mammalian neutral sphingomyelinase-3 is a C-tail-anchored protein". J. Biol. Chem. 281 (19): 13784–93. doi:10.1074/jbc.M511306200. PMID 16517606.
• Levy M, Castillo SS, Goldkorn T (2006). "nSMase2 activation and trafficking are modulated by oxidative stress to induce apoptosis". Biochem. Biophys. Res. Commun. 344 (3): 900–5. doi:10.1016/j.bbrc.2006.04.013. PMC 4370275. PMID 16631623.
• Clarke CJ, Truong TG, Hannun YA (2007). "Role for neutral sphingomyelinase-2 in tumor necrosis factor alpha-stimulated expression of vascular cell adhesion molecule-1 (VCAM) and intercellular adhesion molecule-1 (ICAM) in lung epithelial cells: p38 MAPK is an upstream regulator of nSMase2". J. Biol. Chem. 282 (2): 1384–96. doi:10.1074/jbc.M609216200. PMID 17085432.
• Tani M, Hannun YA (2007). "Analysis of membrane topology of neutral sphingomyelinase 2". FEBS Lett. 581 (7): 1323–8. doi:10.1016/j.febslet.2007.02.046. PMC 1868537. PMID 17349629.
• Filosto S, Fry W, Knowlton A, Goldkorn T (2010). "Neutral sphingomyelinase 2 (nSMase2) is a phosphoprotein regulated by calcineurin (PP2B)". J. Biol. Chem. 285 (14): 10213–22. doi:10.1074/jbc.M109.069963. PMC 2856226. PMID 20106976.