SNIP1

Smad nuclear-interacting protein 1 is a protein that in humans is encoded by the SNIP1 gene.[5][6][7]

SNIP1
Identifiers
Aliases	SNIP1, PMRED, Smad nuclear interacting protein 1, PML1
External IDs	OMIM: 608241 MGI: 2156003 HomoloGene: 110886 GeneCards: SNIP1
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p34.3 Start 37,534,449 bp[1] End 37,554,293 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 D2.2 Start 125,066,672 bp[2] End 125,074,042 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • mRNA binding • RNA binding Cellular component • nucleoplasm • cell nucleus • cytosol • U2-type precatalytic spliceosome Biological process • positive regulation of protein targeting to mitochondrion • I-kappaB kinase/NF-kappaB signaling • gene silencing by RNA • regulation of transcription, DNA-templated • production of miRNAs involved in gene silencing by miRNA • mRNA splicing, via spliceosome Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	79753	76793
Ensembl	ENSG00000163877	ENSMUSG00000050213
UniProt	Q8TAD8	Q8BIZ6
RefSeq (mRNA)	NM_024700	NM_175246 NM_001356560
RefSeq (protein)	NP_078976	NP_780455 NP_001343489
Location (UCSC)	Chr 1: 37.53 – 37.55 Mb	Chr 4: 125.07 – 125.07 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

SNIP1 has been shown to interact with EP300.[5]

References

1. GRCh38: Ensembl release 89: ENSG00000163877 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000050213 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Kim RH, Wang D, Tsang M, Martin J, Huff C, de Caestecker MP, Parks WT, Meng X, Lechleider RJ, Wang T, Roberts AB (2000). "A novel smad nuclear interacting protein, SNIP1, suppresses p300-dependent TGF-beta signal transduction". Genes Dev. 14 (13): 1605–16. doi:10.1101/gad.14.13.1605 (inactive 2021-01-31). PMC 316742. PMID 10887155.CS1 maint: DOI inactive as of January 2021 (link)
6. Roche KC, Wiechens N, Owen-Hughes T, Perkins ND (2004). "The FHA domain protein SNIP1 is a regulator of the cell cycle and cyclin D1 expression". Oncogene. 23 (50): 8185–8195. doi:10.1038/sj.onc.1208025. PMID 15378006.
7. "Entrez Gene: SNIP1 Smad nuclear interacting protein 1".

Further reading

• Kim RH, Flanders KC, Birkey Reffey S, Anderson LA, Duckett CS, Perkins ND, Roberts AB (2001). "SNIP1 inhibits NF-kappa B signaling by competing for its binding to the C/H1 domain of CBP/p300 transcriptional co-activators". J. Biol. Chem. 276 (49): 46297–46304. doi:10.1074/jbc.M103819200. PMID 11567019.
• Lin Y, Martin J, Gruendler C, Farley J, Meng X, Li BY, Lechleider R, Huff C, Kim RH, Grasser WA, Paralkar V, Wang T (2002). "A novel link between the proteasome pathway and the signal transduction pathway of the bone morphogenetic proteins (BMPs)". BMC Cell Biol. 3: 15. doi:10.1186/1471-2121-3-15. PMC 117437. PMID 12097147.
• Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–1332. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Cui Q, Lim SK, Zhao B, Hoffmann FM (2005). "Selective inhibition of TGF-beta responsive genes by Smad-interacting peptide aptamers from FoxH1, Lef1 and CBP". Oncogene. 24 (24): 3864–3874. doi:10.1038/sj.onc.1208556. PMID 15750622.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–648. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
• Fujii M, Lyakh LA, Bracken CP, Fukuoka J, Hayakawa M, Tsukiyama T, Soll SJ, Harris M, Rocha S, Roche KC, Tominaga S, Jen J, Perkins ND, Lechleider RJ, Roberts AB (2006). "SNIP1 is a candidate modifier of the transcriptional activity of c-Myc on E box-dependent target genes". Mol. Cell. 24 (5): 771–783. doi:10.1016/j.molcel.2006.11.006. PMID 17157259.