SOX7

SRY-box 7 is a protein that in humans is encoded by the SOX7 gene. [5]

SOX7
Identifiers
Aliases	SOX7, SRY-box 7, SRY-box transcription factor 7
External IDs	OMIM: 612202 MGI: 98369 HomoloGene: 7949 GeneCards: SOX7
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8p23.1 Start 10,723,768 bp[1] End 10,730,511 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 D1 Start 63,943,673 bp[2] End 63,950,732 bp[2]
Gene ontology Molecular function • DNA binding • GO:0001948 protein binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding • sequence-specific DNA binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component • cytoplasm • cell nucleus • nucleoplasm Biological process • regulation of canonical Wnt signaling pathway • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process • endoderm formation • negative regulation of transcription, DNA-templated • regulation of transcription, DNA-templated • transcription, DNA-templated • negative regulation of cell proliferation • regulation of transcription from RNA polymerase II promoter • positive regulation of transcription, DNA-templated • negative regulation of transcription from RNA polymerase II promoter • cell differentiation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	83595	20680
Ensembl	ENSG00000171056 ENSG00000285438	ENSMUSG00000063060
UniProt	Q9BT81	P40646
RefSeq (mRNA)	NM_031439	NM_011446
RefSeq (protein)	NP_113627	NP_035576
Location (UCSC)	Chr 8: 10.72 – 10.73 Mb	Chr 14: 63.94 – 63.95 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The protein may play a role in tumorigenesis. A similar protein in mice is involved in the regulation of the wingless-type MMTV integration site family (Wnt) pathway. [provided by RefSeq, Jul 2008].

References

1. ENSG00000285438 GRCh38: Ensembl release 89: ENSG00000171056, ENSG00000285438 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000063060 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: SRY-box 7". Retrieved 2018-05-26.

Further reading

• Takash W, Cañizares J, Bonneaud N, Poulat F, Mattéi MG, Jay P, Berta P (November 2001). "SOX7 transcription factor: sequence, chromosomal localisation, expression, transactivation and interference with Wnt signalling". Nucleic Acids Res. 29 (21): 4274–83. doi:10.1093/nar/29.21.4274. PMC 60197. PMID 11691915.
• Séguin CA, Draper JS, Nagy A, Rossant J (August 2008). "Establishment of endoderm progenitors by SOX transcription factor expression in human embryonic stem cells". Cell Stem Cell. 3 (2): 182–95. doi:10.1016/j.stem.2008.06.018. PMID 18682240.
• Guo L, Zhong D, Lau S, Liu X, Dong XY, Sun X, Yang VW, Vertino PM, Moreno CS, Varma V, Dong JT, Zhou W (September 2008). "Sox7 Is an independent checkpoint for beta-catenin function in prostate and colon epithelial cells". Mol. Cancer Res. 6 (9): 1421–30. doi:10.1158/1541-7786.MCR-07-2175. PMC 2652859. PMID 18819930.
• Semb H (October 2008). "Expandable endodermal progenitors: new tools to explore endoderm and its derivatives". Cell Stem Cell. 3 (4): 355–6. doi:10.1016/j.stem.2008.09.010. PMID 18940723.
• Zhang Y, Huang S, Dong W, Li L, Feng Y, Pan L, Han Z, Wang X, Ren G, Su D, Huang B, Lu J (May 2009). "SOX7, down-regulated in colorectal cancer, induces apoptosis and inhibits proliferation of colorectal cancer cells". Cancer Lett. 277 (1): 29–37. doi:10.1016/j.canlet.2008.11.014. PMID 19108950.
• Zhou X, Huang SY, Feng JX, Gao YY, Zhao L, Lu J, Huang BQ, Zhang Y (November 2011). "SOX7 is involved in aspirin-mediated growth inhibition of human colorectal cancer cells". World J. Gastroenterol. 17 (44): 4922–7. doi:10.3748/wjg.v17.i44.4922. PMC 3235637. PMID 22171135.
• Fan R, Zhang LY, Wang H, Yang B, Han T, Zhao XL, Wang W, Wang XQ, Lin GW (June 2012). "Methylation of the CpG island near SOX7 gene promoter is correlated with the poor prognosis of patients with myelodysplastic syndrome". Tohoku J. Exp. Med. 227 (2): 119–28. doi:10.1620/tjem.227.119. PMID 22706399.
• Li B, Ge Z, Song S, Zhang S, Yan H, Huang B, Zhang Y (October 2012). "Decreased expression of SOX7 is correlated with poor prognosis in lung adenocarcinoma patients". Pathol. Oncol. Res. 18 (4): 1039–45. doi:10.1007/s12253-012-9542-8. PMID 22777918. S2CID 10156272.
• Chan DW, Mak CS, Leung TH, Chan KK, Ngan HY (December 2012). "Down-regulation of Sox7 is associated with aberrant activation of Wnt/b-catenin signaling in endometrial cancer". Oncotarget. 3 (12): 1546–56. doi:10.18632/oncotarget.667. PMC 3681493. PMID 23295859.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.