SP140 (gene)

SP140 nuclear body protein is a protein that in humans is encoded by the SP140 gene. [5]

SP140
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2MD7, 2MD8
Identifiers
Aliases	SP140, LYSP100, LYSP100-A, LYSP100-B, SP140 nuclear body protein
External IDs	OMIM: 608602 MGI: 3702467 HomoloGene: 128391 GeneCards: SP140
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q37.1 Start 230,203,110 bp[1] End 230,313,215 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 C5 Start 85,600,378 bp[2] End 85,645,037 bp[2]
Gene ontology Molecular function • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • DNA binding • GO:0001948 protein binding • metal ion binding Cellular component • cytoplasm • PML body • nuclear envelope • mitochondrion • cell nucleus • nucleoplasm • fibrillar center • nuclear body Biological process • defense response • regulation of transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	11262	434484
Ensembl	ENSG00000079263	ENSMUSG00000070031
UniProt	Q13342	n/a
RefSeq (mRNA)	NM_001005176 NM_001278451 NM_001278452 NM_001278453 NM_007237	NM_001013817
RefSeq (protein)	NP_001005176 NP_001265380 NP_001265381 NP_001265382 NP_009168	n/a
Location (UCSC)	Chr 2: 230.2 – 230.31 Mb	Chr 1: 85.6 – 85.65 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000079263 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000070031 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: SP140 nuclear body protein". Retrieved 2016-09-07.

Further reading

• Madani N, Millette R, Platt EJ, Marin M, Kozak SL, Bloch DB, Kabat D (2002). "Implication of the lymphocyte-specific nuclear body protein Sp140 in an innate response to human immunodeficiency virus type 1". J. Virol. 76 (21): 11133–8. doi:10.1128/jvi.76.21.11133-11138.2002. PMC 136615. PMID 12368356.

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human Nuclear body protein SP140