SPACA3

Sperm acrosome membrane-associated protein 3 is a protein that in humans is encoded by the SPACA3 gene. It may be involved in adhesion to the egg before the egg is fertilized.[5][6]

SPACA3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4YF2
Identifiers
Aliases	SPACA3, 1700025M08Rik, ALLP17, CT54, LYC3, LYZL3, SLLP1, LYZC, sperm acrosome associated 3
External IDs	OMIM: 612749 MGI: 1922872 HomoloGene: 18365 GeneCards: SPACA3
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q11.2 Start 32,970,376 bp[1] End 32,997,877 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 B5 Start 80,858,365 bp[2] End 80,867,814 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • lysozyme activity Cellular component • integral component of membrane • extracellular region • Acrosome • secretory granule • membrane • cytoplasmic vesicle • extracellular • acrosomal membrane • acrosomal matrix Biological process • monocyte activation • cell wall macromolecule catabolic process • fertilization • positive regulation of phagocytosis • response to virus • positive regulation of macrophage activation • sperm-egg recognition • defense response to Gram-positive bacterium • peptidoglycan catabolic process • defense response to Gram-negative bacterium • fusion of sperm to egg plasma membrane involved in single fertilization Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	124912	75622
Ensembl	ENSG00000141316	ENSMUSG00000053184
UniProt	Q8IXA5	Q9D9X8
RefSeq (mRNA)	NM_173847 NM_001317225 NM_001317226	NM_029367 NM_001359183
RefSeq (protein)	NP_001304154 NP_001304155 NP_776246	NP_083643 NP_001346112
Location (UCSC)	Chr 17: 32.97 – 33 Mb	Chr 11: 80.86 – 80.87 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000141316 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000053184 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Mandal A, Klotz KL, Shetty J, Jayes FL, Wolkowicz MJ, Bolling LC, Coonrod SA, Black MB, Diekman AB, Haystead TA, Flickinger CJ, Herr JC (Apr 2003). "SLLP1, a unique, intra-acrosomal, non-bacteriolytic, c lysozyme-like protein of human spermatozoa". Biol Reprod. 68 (5): 1525–37. doi:10.1095/biolreprod.102.010108. PMID 12606493.
6. "Entrez Gene: SPACA3 sperm acrosome associated 3".

Further reading

• Niyonsaba F, Ogawa H (2006). "Protective roles of the skin against infection: implication of naturally occurring human antimicrobial agents beta-defensins, cathelicidin LL-37 and lysozyme". J. Dermatol. Sci. 40 (3): 157–68. doi:10.1016/j.jdermsci.2005.07.009. PMID 16150577.
• Cramer EM, Breton-Gorius J (1987). "Ultrastructural localization of lysozyme in human neutrophils by immunogold". J. Leukoc. Biol. 41 (3): 242–7. doi:10.1002/jlb.41.3.242. PMID 3470418. S2CID 32012371.
• Welsh IR, Spitznagel JK (1973). "Distribution of lysosomal enzymes, cationic proteins, and bactericidal substances in subcellular fractions of human polymorphonuclear leukocytes". Infect. Immun. 4 (2): 97–102. doi:10.1128/IAI.4.2.97-102.1971. PMC 416271. PMID 5154881.
• Ibrahim HR, Matsuzaki T, Aoki T (2001). "Genetic evidence that antibacterial activity of lysozyme is independent of its catalytic function". FEBS Lett. 506 (1): 27–32. doi:10.1016/S0014-5793(01)02872-1. PMID 11591365. S2CID 21593262.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Wang Z, Zhang Y, Mandal A, et al. (2005). "The spermatozoa protein, SLLP1, is a novel cancer-testis antigen in hematologic malignancies". Clin. Cancer Res. 10 (19): 6544–50. doi:10.1158/1078-0432.CCR-04-0911. PMID 15475442.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Zhang K, Gao R, Zhang H, et al. (2006). "Molecular cloning and characterization of three novel lysozyme-like genes, predominantly expressed in the male reproductive system of humans, belonging to the c-type lysozyme/alpha-lactalbumin family". Biol. Reprod. 73 (5): 1064–71. doi:10.1095/biolreprod.105.041889. PMID 16014814. S2CID 21603980.