SPDYA

Speedy protein A is a protein that in humans is encoded by the SPDYA gene.[5][6][7][8]

SPDYA
Identifiers
Aliases	SPDYA, RINGO3, RINGOA, SPDY1, SPY1, speedy/RINGO cell cycle regulator family member A
External IDs	OMIM: 614029 MGI: 1918141 HomoloGene: 16357 GeneCards: SPDYA
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p23.2 Start 28,782,517 bp[1] End 28,850,611 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 E1.3 Start 71,552,061 bp[2] End 71,589,533 bp[2]
Gene ontology Molecular function • protein kinase binding • protein kinase activator activity Cellular component • cell nucleus • nucleoplasm Biological process • multicellular organism development • cell cycle • positive regulation of cyclin-dependent protein serine/threonine kinase activity • male meiotic nuclear division • positive regulation of cell proliferation • cellular response to DNA damage stimulus • activation of protein kinase activity • positive regulation of protein kinase activity • G1/S transition of mitotic cell cycle Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	245711	70891
Ensembl	ENSG00000163806	ENSMUSG00000052525
UniProt	Q5MJ70	Q5IBH7
RefSeq (mRNA)	NM_182756 NM_001008779 NM_001142634	NM_001142631 NM_029254
RefSeq (protein)	NP_001008779 NP_001136106 NP_877433	NP_001136103 NP_083530
Location (UCSC)	Chr 2: 28.78 – 28.85 Mb	Chr 17: 71.55 – 71.59 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

SPDYA has been shown to interact with CDKN1B.[9]

References

1. GRCh38: Ensembl release 89: ENSG00000163806 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000052525 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Porter LA, Dellinger RW, Tynan JA, Barnes EA, Kong M, Lenormand JL, Donoghue DJ (Apr 2002). "Human Speedy: a novel cell cycle regulator that enhances proliferation through activation of Cdk2". The Journal of Cell Biology. 157 (3): 357–66. doi:10.1083/jcb.200109045. PMC 2173287. PMID 11980914.
6. Barnes EA, Porter LA, Lenormand JL, Dellinger RW, Donoghue DJ (Jul 2003). "Human Spy1 promotes survival of mammalian cells following DNA damage". Cancer Research. 63 (13): 3701–7. PMID 12839962.
7. Cheng A, Xiong W, Ferrell JE, Solomon MJ (Jan 2005). "Identification and comparative analysis of multiple mammalian Speedy/Ringo proteins". Cell Cycle. 4 (1): 155–65. doi:10.4161/cc.4.1.1347. PMID 15611625.
8. "Entrez Gene: SPDYA speedy homolog A (Drosophila)".
9. Porter LA, Kong-Beltran M, Donoghue DJ (Sep 2003). "Spy1 interacts with p27Kip1 to allow G1/S progression". Molecular Biology of the Cell. 14 (9): 3664–74. doi:10.1091/mbc.E02-12-0820. PMC 196558. PMID 12972555.

Further reading

• Porter LA, Kong-Beltran M, Donoghue DJ (Sep 2003). "Spy1 interacts with p27Kip1 to allow G1/S progression". Molecular Biology of the Cell. 14 (9): 3664–74. doi:10.1091/mbc.E02-12-0820. PMC 196558. PMID 12972555.
• Gastwirt RF, Slavin DA, McAndrew CW, Donoghue DJ (Nov 2006). "Spy1 expression prevents normal cellular responses to DNA damage: inhibition of apoptosis and checkpoint activation". The Journal of Biological Chemistry. 281 (46): 35425–35. doi:10.1074/jbc.M604720200. PMID 16951407.
• McAndrew CW, Gastwirt RF, Meyer AN, Porter LA, Donoghue DJ (Aug 2007). "Spy1 enhances phosphorylation and degradation of the cell cycle inhibitor p27". Cell Cycle. 6 (15): 1937–45. doi:10.4161/cc.6.15.4520. PMID 17671428.