SPEF1

Sperm flagellar protein 1 is a protein that in humans is encoded by the SPEF1 gene.[5][6]

SPEF1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2EE7
Identifiers
Aliases	SPEF1, C20orf28, CLAMP, SPEF1A, sperm flagellar 1
External IDs	OMIM: 610674 MGI: 3513546 HomoloGene: 15741 GeneCards: SPEF1
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20p13 Start 3,777,504 bp[1] End 3,781,448 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 F1|2 Start 131,170,261 bp[2] End 131,187,282 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • microtubule binding • molecular function Cellular component • cytoplasm • GO:0035085 axoneme • cell projection • motile cilium • cilium • cytoskeleton • cellular component Biological process • negative regulation of microtubule depolymerization • cell migration • biological process • cilium-dependent cell motility • regulation of cytoskeleton organization Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	25876	70997
Ensembl	ENSG00000101222	ENSMUSG00000027329
UniProt	Q9Y4P9	Q99JL1
RefSeq (mRNA)	NM_015417	NM_027641
RefSeq (protein)	NP_056232	NP_081917
Location (UCSC)	Chr 20: 3.78 – 3.78 Mb	Chr 2: 131.17 – 131.19 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000101222 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027329 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Chan SW, Fowler KJ, Choo KH, Kalitsis P (Jul 2005). "Spef1, a conserved novel testis protein found in mouse sperm flagella". Gene. 353 (2): 189–99. doi:10.1016/j.gene.2005.04.025. PMID 15979255.
6. "Entrez Gene: C20orf28 chromosome 20 open reading frame 28".

Further reading

• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Dougherty GW, Adler HJ, Rzadzinska A, et al. (2006). "CLAMP, a novel microtubule-associated protein with EB-type calponin homology". Cell Motil. Cytoskeleton. 62 (3): 141–56. doi:10.1002/cm.20093. PMID 16206169.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.