SPIN1

Spindlin-1 is a protein that in humans is encoded by the SPIN1 gene.[5][6]

SPIN1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2NS2, 4H75, 4MZF, 4MZG, 4MZH
Identifiers
Aliases	SPIN1, SPIN, TDRD24, spindlin 1
External IDs	OMIM: 609936 MGI: 109242 HomoloGene: 55983 GeneCards: SPIN1
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q22.1 Start 88,388,430 bp[1] End 88,478,694 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13 A5|13 26.04 cM Start 51,100,880 bp[2] End 51,152,546 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • methylated histone binding • GO:0001948 protein binding Cellular component • cell nucleus • spindle • nucleolus • nucleoplasm • cytosol • not the membrane Biological process • multicellular organism development • Wnt signaling pathway • cell cycle • GO:0007126 meiotic cell cycle • rRNA transcription • gamete generation • positive regulation of Wnt signaling pathway • positive regulation of transcription, DNA-templated • chromatin organization Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10927	20729
Ensembl	ENSG00000106723	ENSMUSG00000021395
UniProt	Q9Y657	Q61142
RefSeq (mRNA)	NM_006717	NM_001283028 NM_001283029 NM_001283030 NM_011462 NM_146043
RefSeq (protein)	NP_006708	NP_001269957 NP_001269958 NP_001269959 NP_035592 NP_666155
Location (UCSC)	Chr 9: 88.39 – 88.48 Mb	Chr 13: 51.1 – 51.15 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000106723 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000021395 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Gao Y, Yue W, Zhang P, Li L, Xie X, Yuan H, Chen L, Liu D, Yan F, Pei X (Aug 2005). "Spindlin1, a novel nuclear protein with a role in the transformation of NIH3T3 cells". Biochem Biophys Res Commun. 335 (2): 343–50. doi:10.1016/j.bbrc.2005.07.087. PMID 16098913.
6. "Entrez Gene: SPIN1 spindlin 1".

Further reading

• Oh B, Hwang SY, Solter D, Knowles BB (1997). "Spindlin, a major maternal transcript expressed in the mouse during the transition from oocyte to embryo". Development. 124 (2): 493–503. PMID 9053325.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
• Jiang F, Zhao Q, Qin L, et al. (2006). "Expression, purification, crystallization and preliminary X-ray analysis of human spindlin1, an ovarian cancer-related protein". Protein Pept. Lett. 13 (2): 203–5. doi:10.2174/092986606775101661. PMID 16472086.
• Zhao Q, Qin L, Jiang F, et al. (2007). "Structure of human spindlin1. Tandem tudor-like domains for cell cycle regulation". J. Biol. Chem. 282 (1): 647–56. doi:10.1074/jbc.M604029200. PMID 17082182.