SPINK2

Serine protease inhibitor Kazal-type 2 also known as acrosin-trypsin inhibitor is a protein that in humans is encoded by the SPINK2 gene.[3][4]

SPINK2
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2JXD
Identifiers
Aliases	SPINK2, HUSI-II, serine peptidase inhibitor, Kazal type 2, SPGF29, serine peptidase inhibitor Kazal type 2
External IDs	OMIM: 605753 HomoloGene: 77717 GeneCards: SPINK2
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q12 Start 56,809,860 bp[1] End 56,821,742 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • peptidase inhibitor activity • endopeptidase inhibitor activity • GO:0001948 protein binding • serine-type endopeptidase inhibitor activity Cellular component • extracellular region • Acrosome • extracellular • cytoplasmic vesicle Biological process • regulation of acrosome reaction • negative regulation of peptidase activity • negative regulation of serine-type endopeptidase activity • spermatogenesis • acrosome assembly • spermatid development Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6691	n/a
Ensembl	ENSG00000128040	n/a
UniProt	P20155	n/a
RefSeq (mRNA)	NM_001271718 NM_001271719 NM_001271720 NM_001271721 NM_001271722 NM_021114	n/a
RefSeq (protein)	NP_001258647 NP_001258648 NP_001258649 NP_001258650 NP_001258651 NP_066937	n/a
Location (UCSC)	Chr 4: 56.81 – 56.82 Mb	n/a
PubMed search	[2]	n/a
Wikidata
View/Edit Human

See also

• Kazal-type serine protease inhibitor domain

References

1. GRCh38: Ensembl release 89: ENSG00000128040 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Moritz A, Grzeschik KH, Wingender E, Fink E (Mar 1993). "Organization and sequence of the gene encoding the human acrosin-trypsin inhibitor (HUSI-II)". Gene. 123 (2): 277–81. doi:10.1016/0378-1119(93)90138-S. PMID 8428671.
4. "Entrez Gene: SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)".

[1]

Further reading

• Wapenaar MC, Monsuur AJ, Poell J, et al. (2007). "The SPINK gene family and celiac disease susceptibility". Immunogenetics. 59 (5): 349–57. doi:10.1007/s00251-007-0199-5. PMC 1914236. PMID 17333166.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rockett JC, Patrizio P, Schmid JE, et al. (2004). "Gene expression patterns associated with infertility in humans and rodent models". Mutat. Res. 549 (1–2): 225–40. doi:10.1016/j.mrfmmm.2003.11.017. PMID 15120973.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Fink E, Hehlein-Fink C, Eulitz M (1990). "Amino acid sequence elucidation of human acrosin-trypsin inhibitor (HUSI-II) reveals that Kazal-type proteinase inhibitors are structurally related to beta-subunits of glycoprotein hormones" (PDF). FEBS Lett. 270 (1–2): 222–4. doi:10.1016/0014-5793(90)81273-Q. PMID 2226783. S2CID 1068212.
• Collins J, Taube W, Fink E, et al. (1992). "Variants of human seminal acrosin inhibitor (HUSI-II) which inhibit human leukocyte elastase". Biomed. Biochim. Acta. 50 (4–6): 683–5. PMID 1801743.
• Möritz A, Lilja H, Fink E (1991). "Molecular cloning and sequence analysis of the cDNA encoding the human acrosin-trypsin inhibitor (HUSI-II)". FEBS Lett. 278 (1): 127–30. doi:10.1016/0014-5793(91)80099-O. PMID 1704312. S2CID 34332531.
• Dietl T, Kruck J, Schill WB, Fritz H (1977). "Localization of seminal plasma proteinase inhibitors in human spermatozoa as revealed by the indirect immunofluorescence technique". Hoppe-Seyler's Z. Physiol. Chem. 357 (10): 1333–7. doi:10.1515/bchm2.1976.357.2.1333. PMID 791787.

1. Lee B, Park I, Jin S, Choi H, Kwon JT, Kim J, Jeong J, Cho BN, Eddy EM, Cho C (2011). "Impaired spermatogenesis and fertility in mice carrying a mutation in the Spink2 gene expressed predominantly in testes". J. Biol. Chem. 286 (33): 29108–17. doi:10.1074/jbc.M111.244905. PMC 3190718. PMID 21705336.