SPRR1A

Cornifin-A is a protein that in humans is encoded by the SPRR1A gene.[5][6]

SPRR1A
Identifiers
Aliases	SPRR1A, SPRK, small proline rich protein 1A
External IDs	OMIM: 182265 MGI: 106660 HomoloGene: 105698 GeneCards: SPRR1A
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q21.3 Start 152,985,231 bp[1] End 152,985,500 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3 F1|3 40.14 cM Start 92,483,952 bp[2] End 92,485,895 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • protein binding, bridging • GO:0001948 protein binding • structural molecule activity • structural constituent of epidermis Cellular component • cytoplasm • cornified envelope • cytosol Biological process • peptide cross-linking • keratinization • keratinocyte differentiation • epidermis development • cornification Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6698	20753
Ensembl	ENSG00000169474	ENSMUSG00000050359
UniProt	P35321	Q62266
RefSeq (mRNA)	NM_005987 NM_001199828	NM_009264
RefSeq (protein)	NP_001186757 NP_005978	NP_033290
Location (UCSC)	Chr 1: 152.99 – 152.99 Mb	Chr 3: 92.48 – 92.49 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000169474 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000050359 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Gibbs S, Fijneman R, Wiegant J, van Kessel AG, van De Putte P, Backendorf C (June 1993). "Molecular characterization and evolution of the SPRR family of keratinocyte differentiation markers encoding small proline-rich proteins". Genomics. 16 (3): 630–7. doi:10.1006/geno.1993.1240. PMID 8325635.
6. "Entrez Gene: SPRR1A small proline-rich protein 1A".

Further reading

• Greco MA, Lorand L, Lane WS, Baden HP, Parameswaran KN, Kvedar JC (February 1995). "The pancornulins: a group of small proline rich-related cornified envelope precursors with bifunctional capabilities in isopeptide bond formation". The Journal of Investigative Dermatology. 104 (2): 204–10. doi:10.1111/1523-1747.ep12612759. PMID 7829876.
• Robinson PA, Marley JJ, High AS, Hume WJ (March 1994). "Differential expression of protease inhibitor and small proline-rich protein genes between normal human oral tissue and odontogenic keratocysts". Archives of Oral Biology. 39 (3): 251–9. doi:10.1016/0003-9969(94)90051-5. PMID 8018055.
• Fujimoto W, Nakanishi G, Arata J, Jetten AM (February 1997). "Differential expression of human cornifin alpha and beta in squamous differentiating epithelial tissues and several skin lesions". The Journal of Investigative Dermatology. 108 (2): 200–4. doi:10.1111/1523-1747.ep12334240. PMID 9008234.
• Robinson NA, Lapic S, Welter JF, Eckert RL (May 1997). "S100A11, S100A10, annexin I, desmosomal proteins, small proline-rich proteins, plasminogen activator inhibitor-2, and involucrin are components of the cornified envelope of cultured human epidermal keratinocytes". The Journal of Biological Chemistry. 272 (18): 12035–46. doi:10.1074/jbc.272.18.12035. PMID 9115270.
• Reddy SP, Konkin T, Wu R (December 1998). "Structure and organization of the genes encoding mouse small proline-rich proteins, mSPRR1A and 1B". Gene. 224 (1–2): 59–66. doi:10.1016/S0378-1119(98)00507-1. PMID 9931436.
• Candi E, Tarcsa E, Idler WW, Kartasova T, Marekov LN, Steinert PM (March 1999). "Transglutaminase cross-linking properties of the small proline-rich 1 family of cornified cell envelope proteins. Integration with loricrin". The Journal of Biological Chemistry. 274 (11): 7226–37. doi:10.1074/jbc.274.11.7226. PMID 10066784.
• Lee CH, Marekov LN, Kim S, Brahim JS, Park MH, Steinert PM (July 2000). "Small proline-rich protein 1 is the major component of the cell envelope of normal human oral keratinocytes". FEBS Letters. 477 (3): 268–72. doi:10.1016/S0014-5793(00)01806-8. PMID 10908733.
• Hartley JL, Temple GF, Brasch MA (November 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Cabral A, Voskamp P, Cleton-Jansen AM, South A, Nizetic D, Backendorf C (June 2001). "Structural organization and regulation of the small proline-rich family of cornified envelope precursors suggest a role in adaptive barrier function". The Journal of Biological Chemistry. 276 (22): 19231–7. doi:10.1074/jbc.M100336200. PMID 11279051.
• Bonilla IE, Tanabe K, Strittmatter SM (February 2002). "Small proline-rich repeat protein 1A is expressed by axotomized neurons and promotes axonal outgrowth". The Journal of Neuroscience. 22 (4): 1303–15. doi:10.1523/JNEUROSCI.22-04-01303.2002. PMC 6757578. PMID 11850458.