SPRR3

Small proline-rich protein 3 is a protein that in humans is encoded by the SPRR3 gene,[5][6] which is found within the epidermal differentiation complex (EDC).[7]

SPRR3
Identifiers
Aliases	SPRR3, small proline rich protein 3
External IDs	OMIM: 182271 MGI: 1330237 HomoloGene: 135951 GeneCards: SPRR3
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q21.3 Start 153,001,747 bp[1] End 153,003,856 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3 F1|3 40.14 cM Start 92,456,502 bp[2] End 92,458,720 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • structural molecule activity • GO:0001948 protein binding Cellular component • extracellular exosome • cytoplasm • cornified envelope • cytosol • Golgi apparatus • perinuclear region of cytoplasm Biological process • wound healing • keratinization • keratinocyte differentiation • peptide cross-linking • epidermis development • cornification Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6707	20766
Ensembl	ENSG00000163209	ENSMUSG00000045539
UniProt	Q9UBC9	O09116
RefSeq (mRNA)	NM_005416 NM_001097589	NM_001204427 NM_011478
RefSeq (protein)	NP_001091058 NP_005407	NP_001191356 NP_035608
Location (UCSC)	Chr 1: 153 – 153 Mb	Chr 3: 92.46 – 92.46 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000163209 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000045539 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Gibbs S, Fijneman R, Wiegant J, van Kessel AG, van De Putte P, Backendorf C (June 1993). "Molecular characterization and evolution of the SPRR family of keratinocyte differentiation markers encoding small proline-rich proteins". Genomics. 16 (3): 630–7. doi:10.1006/geno.1993.1240. PMID 8325635.
6. "Entrez Gene: SPRR3 small proline-rich protein 3".
7. Kypriotou M, Huber M, Hohl D (September 2012). "The human epidermal differentiation complex: cornified envelope precursors, S100 proteins and the 'fused genes' family". Experimental Dermatology. 21 (9): 643–9. doi:10.1111/j.1600-0625.2012.01472.x. PMID 22507538.

Further reading

• Greco MA, Lorand L, Lane WS, Baden HP, Parameswaran KN, Kvedar JC (February 1995). "The pancornulins: a group of small proline rich-related cornified envelope precursors with bifunctional capabilities in isopeptide bond formation". The Journal of Investigative Dermatology. 104 (2): 204–10. doi:10.1111/1523-1747.ep12612759. PMID 7829876.
• Robinson PA, Marley JJ, High AS, Hume WJ (March 1994). "Differential expression of protease inhibitor and small proline-rich protein genes between normal human oral tissue and odontogenic keratocysts". Archives of Oral Biology. 39 (3): 251–9. doi:10.1016/0003-9969(94)90051-5. PMID 8018055.
• Abraham JM, Wang S, Suzuki H, Jiang HY, Rosenblum-Vos LS, Yin J, Meltzer SJ (July 1996). "Esophagin cDNA cloning and characterization: a tissue-specific member of the small proline-rich protein family that is not expressed in esophageal tumors". Cell Growth & Differentiation. 7 (7): 855–60. PMID 8809402.
• Steinert PM, Marekov LN (January 1997). "Direct evidence that involucrin is a major early isopeptide cross-linked component of the keratinocyte cornified cell envelope". The Journal of Biological Chemistry. 272 (3): 2021–30. doi:10.1074/jbc.272.3.2021. PMID 8999895.
• Steinert PM, Candi E, Kartasova T, Marekov L (1998). "Small proline-rich proteins are cross-bridging proteins in the cornified cell envelopes of stratified squamous epithelia". Journal of Structural Biology. 122 (1–2): 76–85. doi:10.1006/jsbi.1998.3957. PMID 9724607.
• Fischer DF, Sark MW, Lehtola MM, Gibbs S, van de Putte P, Backendorf C (January 1999). "Structure and evolution of the human SPRR3 gene: implications for function and regulation". Genomics. 55 (1): 88–99. doi:10.1006/geno.1998.5622. PMID 9889002.
• Steinert PM, Candi E, Tarcsa E, Marekov LN, Sette M, Paci M, Ciani B, Guerrieri P, Melino G (September 1999). "Transglutaminase crosslinking and structural studies of the human small proline rich 3 protein". Cell Death and Differentiation. 6 (9): 916–30. doi:10.1038/sj.cdd.4400568. PMID 10510474.
• Dias Neto E, Correa RG, Verjovski-Almeida S, Briones MR, Nagai MA, da Silva W, Zago MA, Bordin S, Costa FF, Goldman GH, Carvalho AF, Matsukuma A, Baia GS, Simpson DH, Brunstein A, de Oliveira PS, Bucher P, Jongeneel CV, O'Hare MJ, Soares F, Brentani RR, Reis LF, de Souza SJ, Simpson AJ (March 2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proceedings of the National Academy of Sciences of the United States of America. 97 (7): 3491–6. Bibcode:2000PNAS...97.3491D. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
• Marenholz I, Zirra M, Fischer DF, Backendorf C, Ziegler A, Mischke D (March 2001). "Identification of human epidermal differentiation complex (EDC)-encoded genes by subtractive hybridization of entire YACs to a gridded keratinocyte cDNA library". Genome Research. 11 (3): 341–55. doi:10.1101/gr.114801. PMC 311024. PMID 11230159.
• Cabral A, Voskamp P, Cleton-Jansen AM, South A, Nizetic D, Backendorf C (June 2001). "Structural organization and regulation of the small proline-rich family of cornified envelope precursors suggest a role in adaptive barrier function". The Journal of Biological Chemistry. 276 (22): 19231–7. doi:10.1074/jbc.M100336200. PMID 11279051.
• Candi E, Oddi S, Terrinoni A, Paradisi A, Ranalli M, Finazzi-Agró A, Melino G (September 2001). "Transglutaminase 5 cross-links loricrin, involucrin, and small proline-rich proteins in vitro". The Journal of Biological Chemistry. 276 (37): 35014–23. doi:10.1074/jbc.M010157200. PMID 11443109.
• Smolinski KN, Abraham JM, Souza RF, Yin J, Wang S, Xu Y, Zou TT, Kong D, Fleisher AS, Meltzer SJ (June 2002). "Activation of the esophagin promoter during esophageal epithelial cell differentiation". Genomics. 79 (6): 875–80. doi:10.1006/geno.2002.6775. PMID 12036303.
• Katou F, Shirai N, Kamakura S, Tagami H, Nagura H, Motegi K (May 2003). "Differential expression of cornified cell envelope precursors in normal skin, intraorally transplanted skin and normal oral mucosa". The British Journal of Dermatology. 148 (5): 898–905. doi:10.1046/j.1365-2133.2003.05288.x. PMID 12786819. S2CID 31095981.
• Lehr E, Hohl D, Huber M, Brown D (March 2004). "Infection with Human Papillomavirus alters expression of the small proline rich proteins 2 and 3". Journal of Medical Virology. 72 (3): 478–83. doi:10.1002/jmv.20011. PMID 14748073. S2CID 34708572.
• Palmeri D, Zuo FR, Rosen SD, Hemmerich S (May 2004). "Differential gene expression profile of human tonsil high endothelial cells: implications for lymphocyte trafficking". Journal of Leukocyte Biology. 75 (5): 910–27. doi:10.1189/jlb.0903408. PMID 14761935.
• Kimos MC, Wang S, Borkowski A, Yang GY, Yang CS, Perry K, Olaru A, Deacu E, Sterian A, Cottrell J, Papadimitriou J, Sisodia L, Selaru FM, Mori Y, Xu Y, Yin J, Abraham JM, Meltzer SJ (September 2004). "Esophagin and proliferating cell nuclear antigen (PCNA) are biomarkers of human esophageal neoplastic progression". International Journal of Cancer. 111 (3): 415–7. doi:10.1002/ijc.20267. PMID 15221970.
• Hong SH, Nah HY, Lee JY, Lee YJ, Lee JW, Gye MC, Kim CH, Kang BM, Kim MK (June 2004). "Estrogen regulates the expression of the small proline-rich 2 gene family in the mouse uterus". Molecules and Cells. 17 (3): 477–84. PMID 15232223.