SPRY1

Protein sprouty homolog 1 is a protein that in humans is encoded by the SPRY1 gene.[5][6][7]

SPRY1
Identifiers
Aliases	SPRY1, hsprouty RTK signaling antagonist 1
External IDs	OMIM: 602465 MGI: 1345139 HomoloGene: 4266 GeneCards: SPRY1
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q28.1 Start 123,396,795 bp[1] End 123,403,760 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 B Start 37,639,947 bp[2] End 37,644,598 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding Cellular component • Golgi apparatus • membrane • cell membrane • nucleoplasm • cytoplasm • cytosol Biological process • ureteric bud development • negative regulation of neurotrophin TRK receptor signaling pathway • negative regulation of epidermal growth factor receptor signaling pathway • organ induction • bud elongation involved in lung branching • negative regulation of Ras protein signal transduction • multicellular organism development • negative regulation of fibroblast growth factor receptor signaling pathway • GO:0034259 negative regulation of GTPase activity • regulation of signal transduction • negative regulation of MAP kinase activity • establishment of mitotic spindle orientation • metanephros development • negative regulation of cell proliferation • negative regulation of ERK1 and ERK2 cascade • epithelial to mesenchymal transition involved in cardiac fibroblast development Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10252	24063
Ensembl	ENSG00000164056	ENSMUSG00000037211
UniProt	O43609	Q9QXV9
RefSeq (mRNA)	NM_001258038 NM_001258039 NM_005841 NM_199327 NM_001375410	NM_011896 NM_001305440 NM_001305441 NM_001305442
RefSeq (protein)	NP_001244967 NP_001244968 NP_005832 NP_955359 NP_001362339	NP_001292369 NP_001292370 NP_001292371 NP_036026
Location (UCSC)	Chr 4: 123.4 – 123.4 Mb	Chr 3: 37.64 – 37.64 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

See also

• Neurofibromin 1
• SPRED1

References

1. GRCh38: Ensembl release 89: ENSG00000164056 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000037211 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Hacohen N, Kramer S, Sutherland D, Hiromi Y, Krasnow MA (January 1998). "sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airways". Cell. 92 (2): 253–63. doi:10.1016/S0092-8674(00)80919-8. PMID 9458049. S2CID 498977.
6. Haglund K, Schmidt MH, Wong ES, Guy GR, Dikic I (July 2005). "Sprouty2 acts at the Cbl/CIN85 interface to inhibit epidermal growth factor receptor downregulation". EMBO Reports. 6 (7): 635–41. doi:10.1038/sj.embor.7400453. PMC 1369112. PMID 15962011.
7. "Entrez Gene: SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)".

Further reading

• Lim J, Wong ES, Ong SH, Yusoff P, Low BC, Guy GR (October 2000). "Sprouty proteins are targeted to membrane ruffles upon growth factor receptor tyrosine kinase activation. Identification of a novel translocation domain". The Journal of Biological Chemistry. 275 (42): 32837–45. doi:10.1074/jbc.M002156200. PMID 10887178.
• Egan JE, Hall AB, Yatsula BA, Bar-Sagi D (April 2002). "The bimodal regulation of epidermal growth factor signaling by human Sprouty proteins". Proceedings of the National Academy of Sciences of the United States of America. 99 (9): 6041–6. Bibcode:2002PNAS...99.6041E. doi:10.1073/pnas.052090899. PMC 122898. PMID 11983899.
• Hanafusa H, Torii S, Yasunaga T, Nishida E (November 2002). "Sprouty1 and Sprouty2 provide a control mechanism for the Ras/MAPK signalling pathway". Nature Cell Biology. 4 (11): 850–8. doi:10.1038/ncb867. PMID 12402043. S2CID 31064800.
• Di Y, Li J, Zhang Y, He X, Lu H, Xu D, et al. (June 2003). "HCC-associated protein HCAP1, a variant of GEMIN4, interacts with zinc-finger proteins". Journal of Biochemistry. 133 (6): 713–8. doi:10.1093/jb/mvg091. PMID 12869526.
• Wang L, Ji C, Wu H, Xu J, Wu Q, Dai J, et al. (November 2003). "Identification and expression analysis of a novel splice variant of human Sprouty1 gene". International Journal of Molecular Medicine. 12 (5): 783–7. doi:10.3892/ijmm.12.5.783. PMID 14533010.
• Anteby EY, Natanson-Yaron S, Greenfield C, Goldman-Wohl D, Haimov-Kochman R, Holzer H, Yagel S (July 2005). "Human placental Hofbauer cells express sprouty proteins: a possible modulating mechanism of villous branching". Placenta. 26 (6): 476–83. doi:10.1016/j.placenta.2004.08.008. PMID 15950061.
• Cabrita MA, Jäggi F, Widjaja SP, Christofori G (September 2006). "A functional interaction between sprouty proteins and caveolin-1". The Journal of Biological Chemistry. 281 (39): 29201–12. doi:10.1074/jbc.M603921200. PMID 16877379.
• Fritzsche S, Kenzelmann M, Hoffmann MJ, Müller M, Engers R, Gröne HJ, Schulz WA (September 2006). "Concomitant down-regulation of SPRY1 and SPRY2 in prostate carcinoma". Endocrine-Related Cancer. 13 (3): 839–49. doi:10.1677/erc.1.01190. PMID 16954433.
• Schaaf G, Hamdi M, Zwijnenburg D, Lakeman A, Geerts D, Versteeg R, Kool M (January 2010). "Silencing of SPRY1 triggers complete regression of rhabdomyosarcoma tumors carrying a mutated RAS gene". Cancer Research. 70 (2): 762–71. doi:10.1158/0008-5472.CAN-09-2532. PMID 20068162.
• Charles NJ, Huebert RC, Lee S, Adhikari N, Polster S, Rider JE, et al. (September 2010). "Targeted Sprouty1 overexpression in cardiac myocytes does not alter myocardial remodeling or function". Molecular and Cellular Biochemistry. 342 (1–2): 57–62. doi:10.1007/s11010-010-0468-8. PMC 2923832. PMID 20461448.

External links

• SPRY1 human gene location in the UCSC Genome Browser.
• SPRY1 human gene details in the UCSC Genome Browser.