SPSB1

SPRY domain-containing SOCS box protein 1 is a protein that in humans is encoded by the SPSB1 gene.[5][6][7]

SPSB1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2JK9, 3F2O
Identifiers
Aliases	SPSB1, SSB-1, SSB1, splA/ryanodine receptor domain and SOCS box containing 1
External IDs	OMIM: 611657 MGI: 1921896 HomoloGene: 11832 GeneCards: SPSB1
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p36.22 Start 9,292,894 bp[1] End 9,369,532 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 E2 Start 149,896,283 bp[2] End 149,955,043 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • ubiquitin-protein transferase activity • protein binding, bridging involved in substrate recognition for ubiquitination Cellular component • cytoplasm • cytosol • SCF ubiquitin ligase complex Biological process • protein ubiquitination • protein polyubiquitination • post-translational modification • ubiquitin-dependent protein catabolic process • proteasome-mediated ubiquitin-dependent protein catabolic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	80176	74646
Ensembl	ENSG00000171621	ENSMUSG00000039911
UniProt	Q96BD6	Q9D5L7
RefSeq (mRNA)	NM_025106	NM_029035
RefSeq (protein)	NP_079382	NP_083311
Location (UCSC)	Chr 1: 9.29 – 9.37 Mb	Chr 4: 149.9 – 149.96 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000171621 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000039911 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Wang D, Li Z, Messing EM, Wu G (Apr 2005). "The SPRY domain-containing SOCS box protein 1 (SSB-1) interacts with MET and enhances the hepatocyte growth factor-induced Erk-Elk-1-serum response element pathway". J Biol Chem. 280 (16): 16393–401. doi:10.1074/jbc.M413897200. PMID 15713673.
6. Kile BT, Schulman BA, Alexander WS, Nicola NA, Martin HM, Hilton DJ (Jun 2002). "The SOCS box: a tale of destruction and degradation". Trends Biochem Sci. 27 (5): 235–41. doi:10.1016/S0968-0004(02)02085-6. PMID 12076535.
7. "Entrez Gene: SPSB1 splA/ryanodine receptor domain and SOCS box containing 1".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Woo JS, Imm JH, Min CK, et al. (2006). "Structural and functional insights into the B30.2/SPRY domain". EMBO J. 25 (6): 1353–63. doi:10.1038/sj.emboj.7600994. PMC 1422157. PMID 16498413.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.