SRI (gene)

Sorcin is a protein that in humans is encoded by the SRI gene.[5][6]

SRI
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1JUO, 2JC2, 4U8D, 4UPG, 4USL
Identifiers
Aliases	SRI, CP-22, CP22, SCN, V19, sorcin
External IDs	OMIM: 182520 MGI: 98419 HomoloGene: 37736 GeneCards: SRI
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q21.12 Start 88,205,118 bp[1] End 88,226,993 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 A1|5 3.38 cM Start 8,046,078 bp[2] End 8,069,379 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • calcium ion binding • ion channel binding • calcium channel regulator activity • metal ion binding • calcium-dependent cysteine-type endopeptidase activity • protease binding • GO:0001948 protein binding • protein heterodimerization activity • identical protein binding • receptor binding • repressing transcription factor binding Cellular component • axon terminus • dendritic spine neck • vesicle • cytosol • endoplasmic reticulum membrane • membrane • T-tubule • cell membrane • intracellular • sarcoplasmic reticulum • nucleoplasm • smooth endoplasmic reticulum • axon • chromaffin granule membrane • Z disc • mitochondrion • sarcoplasmic reticulum membrane • extracellular exosome • cytoplasm Biological process • regulation of calcium ion transport • regulation of heart contraction • cytoplasmic sequestering of transcription factor • muscle organ development • positive regulation of release of sequestered calcium ion into cytosol • negative regulation of heart rate • proteolysis • negative regulation of ryanodine-sensitive calcium-release channel activity • regulation of cardiac muscle cell contraction • heart development • intracellular sequestering of iron ion • regulation of striated muscle contraction • negative regulation of transcription regulatory region DNA binding • regulation of high voltage-gated calcium channel activity • action potential • positive regulation of insulin secretion involved in cellular response to glucose stimulus • regulation of cell communication by electrical coupling • regulation of cell communication by electrical coupling involved in cardiac conduction • regulation of relaxation of muscle • regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum • calcium ion transport • signal transduction • negative regulation of cardiac muscle contraction • transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6717	109552
Ensembl	ENSG00000075142	ENSMUSG00000003161
UniProt	P30626	Q6P069
RefSeq (mRNA)	NM_001256891 NM_001256892 NM_003130 NM_198901	NM_001080974 NM_025618
RefSeq (protein)	NP_001243820 NP_001243821 NP_003121 NP_944490	NP_001074443 NP_079894
Location (UCSC)	Chr 7: 88.21 – 88.23 Mb	Chr 5: 8.05 – 8.07 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

SRI (gene) has been shown to interact with Ryanodine receptor 2,[7] ANXA7[8] and GCA.[9]

References

1. GRCh38: Ensembl release 89: ENSG00000075142 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000003161 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Van der Bliek AM, Baas F, Van der Velde-Koerts T, Biedler JL, Meyers MB, Ozols RF, Hamilton TC, Joenje H, Borst P (November 1988). "Genes amplified and overexpressed in human multidrug-resistant cell lines". Cancer Research. 48 (21): 5927–32. PMID 2901906.
6. "Entrez Gene: SRI sorcin".
7. Meyers MB, Pickel VM, Sheu SS, Sharma VK, Scotto KW, Fishman GI (November 1995). "Association of sorcin with the cardiac ryanodine receptor". The Journal of Biological Chemistry. 270 (44): 26411–8. doi:10.1074/jbc.270.44.26411. PMID 7592856.
8. Brownawell AM, Creutz CE (August 1997). "Calcium-dependent binding of sorcin to the N-terminal domain of synexin (annexin VII)". The Journal of Biological Chemistry. 272 (35): 22182–90. doi:10.1074/jbc.272.35.22182. PMID 9268363.
9. Hansen C, Tarabykina S, la Cour JM, Lollike K, Berchtold MW (June 2003). "The PEF family proteins sorcin and grancalcin interact in vivo and in vitro". FEBS Letters. 545 (2–3): 151–4. doi:10.1016/S0014-5793(03)00518-0. PMID 12804766. S2CID 42572647.

Further reading

• Rasmussen HH, van Damme J, Puype M, Gesser B, Celis JE, Vandekerckhove J (December 1992). "Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes". Electrophoresis. 13 (12): 960–9. doi:10.1002/elps.11501301199. PMID 1286667. S2CID 41855774.
• Meyers MB, Pickel VM, Sheu SS, Sharma VK, Scotto KW, Fishman GI (November 1995). "Association of sorcin with the cardiac ryanodine receptor". The Journal of Biological Chemistry. 270 (44): 26411–8. doi:10.1074/jbc.270.44.26411. PMID 7592856.
• Meyers MB, Zamparelli C, Verzili D, Dicker AP, Blanck TJ, Chiancone E (January 1995). "Calcium-dependent translocation of sorcin to membranes: functional relevance in contractile tissue". FEBS Letters. 357 (3): 230–4. doi:10.1016/0014-5793(94)01338-2. PMID 7835417. S2CID 28133606.
• Wang SL, Tam MF, Ho YS, Pai SH, Kao MC (February 1995). "Isolation and molecular cloning of human sorcin a calcium-binding protein in vincristine-resistant HOB1 lymphoma cells". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1260 (3): 285–93. doi:10.1016/0167-4781(94)00206-i. PMID 7873602.
• Lee WP (January 1996). "Purification, cDNA cloning, and expression of human sorcin in vincristine-resistant HOB1 lymphoma cell lines". Archives of Biochemistry and Biophysics. 325 (2): 217–26. doi:10.1006/abbi.1996.0027. PMID 8561500.
• Brownawell AM, Creutz CE (August 1997). "Calcium-dependent binding of sorcin to the N-terminal domain of synexin (annexin VII)". The Journal of Biological Chemistry. 272 (35): 22182–90. doi:10.1074/jbc.272.35.22182. PMID 9268363.
• Torigoe K, Harada T, Kusaba H, Uchiumi T, Kohno K, Green ED, Scherer SW, Tsui LC, Schlessinger D, Kuwano M, Wada M (April 1998). "Localization of 67 exons on a YAC contig spanning 1.5 Mb around the multidrug resistance gene region of human chromosome 7q21.1". Genomics. 49 (1): 14–22. doi:10.1006/geno.1997.5200. PMID 9570944.
• Meyers MB, Puri TS, Chien AJ, Gao T, Hsu PH, Hosey MM, Fishman GI (July 1998). "Sorcin associates with the pore-forming subunit of voltage-dependent L-type Ca2+ channels". The Journal of Biological Chemistry. 273 (30): 18930–5. doi:10.1074/jbc.273.30.18930. PMID 9668070.
• Pack-Chung E, Meyers MB, Pettingell WP, Moir RD, Brownawell AM, Cheng I, Tanzi RE, Kim TW (May 2000). "Presenilin 2 interacts with sorcin, a modulator of the ryanodine receptor". The Journal of Biological Chemistry. 275 (19): 14440–5. doi:10.1074/jbc.M909882199. PMID 10748169.
• Xie X, Dwyer MD, Swenson L, Parker MH, Botfield MC (December 2001). "Crystal structure of calcium-free human sorcin: a member of the penta-EF-hand protein family". Protein Science. 10 (12): 2419–25. doi:10.1110/ps.36701. PMC 2374028. PMID 11714909.
• Li G, Tan Y, Yang C, Zhao C, Zhao H, Wang J, Xue Y, Han M, Qian L, Zhao C (July 2002). "Expression and clinical implication of soluble resistance-associated calcium-binding protein gene and multi-drug resistance gene in leukemia". Zhonghua Zhong Liu Za Zhi [Chinese Journal of Oncology]. 24 (4): 370–4. PMID 12408767.
• Li G, Tan Y, Yang C, Zhao C, Zhao H, Wang J, Xue Y, Han M, Qian L, Zhao C (June 2002). "Expression and clinical implications of the soluble drug resistance-related calcium-binding protein (sorcin) gene in leukemia patients". Zhonghua Xue Ye Xue Za Zhi = Zhonghua Xueyexue Zazhi. 23 (6): 293–6. PMID 12411058.
• Meyers MB, Fischer A, Sun YJ, Lopes CM, Rohacs T, Nakamura TY, Zhou YY, Lee PC, Altschuld RA, McCune SA, Coetzee WA, Fishman GI (August 2003). "Sorcin regulates excitation-contraction coupling in the heart". The Journal of Biological Chemistry. 278 (31): 28865–71. doi:10.1074/jbc.M302009200. PMID 12754254.
• Hansen C, Tarabykina S, la Cour JM, Lollike K, Berchtold MW (June 2003). "The PEF family proteins sorcin and grancalcin interact in vivo and in vitro". FEBS Letters. 545 (2–3): 151–4. doi:10.1016/S0014-5793(03)00518-0. PMID 12804766. S2CID 42572647.
• Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (July 2004). "Functional proteomics mapping of a human signaling pathway". Genome Research. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Frank KF, Bölck B, Ding Z, Krause D, Hattebuhr N, Malik A, Brixius K, Hajjar RJ, Schrader J, Schwinger RH (April 2005). "Overexpression of sorcin enhances cardiac contractility in vivo and in vitro". Journal of Molecular and Cellular Cardiology. 38 (4): 607–15. doi:10.1016/j.yjmcc.2005.01.011. PMID 15808837.
• Pope SN, Lee IR (February 2005). "Yeast two-hybrid identification of prostatic proteins interacting with human sex hormone-binding globulin". The Journal of Steroid Biochemistry and Molecular Biology. 94 (1–3): 203–8. doi:10.1016/j.jsbmb.2005.01.007. PMID 15862967. S2CID 9746088.