SRPRB

Signal recognition particle receptor subunit beta is a protein that in humans is encoded by the SRPRB gene.[5][6][7]

SRPRB
Identifiers
Aliases	SRPRB, APMCF1, SRP receptor beta subunit, SRP receptor subunit beta, SR-beta
External IDs	OMIM: 616883 MGI: 102964 HomoloGene: 6332 GeneCards: SRPRB
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q22.1 Start 133,784,023 bp[1] End 133,825,772 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 F1 Start 103,188,032 bp[2] End 103,202,137 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • nucleotide binding • signal recognition particle binding • GTP binding Cellular component • endoplasmic reticulum membrane • cytoplasmic microtubule • cytoplasm • integral component of membrane • signal recognition particle receptor complex • intracellular • endoplasmic reticulum • membrane Biological process • IRE1-mediated unfolded protein response Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	58477	20818
Ensembl	ENSG00000144867	ENSMUSG00000032553
UniProt	Q9Y5M8	P47758
RefSeq (mRNA)	NM_021203 NM_001379313	NM_009275
RefSeq (protein)	NP_067026 NP_001366242	NP_033301
Location (UCSC)	Chr 3: 133.78 – 133.83 Mb	Chr 9: 103.19 – 103.2 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene has similarity to mouse protein which is a subunit of the signal recognition particle receptor (SR). This subunit is a transmembrane GTPase belonging to the GTPase superfamily. It anchors alpha subunit, a peripheral membrane GTPase, to the ER membrane. SR is required for the cotranslational targeting of both secretory and membrane proteins to the ER membrane.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000144867 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000032553 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Miller JD, Tajima S, Lauffer L, Walter P (Mar 1995). "The beta subunit of the signal recognition particle receptor is a transmembrane GTPase that anchors the alpha subunit, a peripheral membrane GTPase, to the endoplasmic reticulum membrane". J Cell Biol. 128 (3): 273–82. doi:10.1083/jcb.128.3.273. PMC 2120348. PMID 7844142.
6. Legate KR, Falcone D, Andrews DW (Oct 2000). "Nucleotide-dependent binding of the GTPase domain of the signal recognition particle receptor beta-subunit to the alpha-subunit". J Biol Chem. 275 (35): 27439–46. doi:10.1074/jbc.M003215200. PMID 10859309.
7. "Entrez Gene: SRPRB signal recognition particle receptor, B subunit".

Further reading

• Bacher G, Pool M, Dobberstein B (1999). "The Ribosome Regulates the Gtpase of the β-Subunit of the Signal Recognition Particle Receptor". J. Cell Biol. 146 (4): 723–30. doi:10.1083/jcb.146.4.723. PMC 2156146. PMID 10459008.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Yan W, Wang WL, Zhu F, et al. (2003). "Isolation of a novel member of small G protein superfamily and its expression in colon cancer". World J. Gastroenterol. 9 (8): 1719–24. doi:10.3748/wjg.v9.i8.1719. PMC 4611530. PMID 12918107.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
• Li Q, Yan W, Cheng S, et al. (2007). "Introduction of G1 phase arrest in Human Hepatocellular carcinoma cells (HHCC) by APMCF1 gene transfection through the down-regulation of TIMP3 and up-regulation of the CDK inhibitors p21". Mol. Biol. Rep. 33 (4): 257–63. doi:10.1007/s11033-006-9007-9. PMID 17080297. S2CID 1871553.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.