SSMEM1

Serine-rich single pass membrane protein 1 is a protein that in humans is encoded by the SSMEM1 gene.[5]

SSMEM1
Identifiers
AliasesSSMEM1, C7orf45, serine-rich single-pass membrane protein 1, serine rich single-pass membrane protein 1
External IDsMGI: 1922897 HomoloGene: 12615 GeneCards: SSMEM1
Gene location (Human)
Chr.Chromosome 7 (human)[1]
Band7q32.2Start130,206,344 bp[1]
End130,216,844 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

136263

75647

Ensembl

ENSG00000165120

ENSMUSG00000029784

UniProt

Q8WWF3

n/a

RefSeq (mRNA)

NM_145268

NM_027073
NM_029373

RefSeq (protein)

NP_660311

n/a

Location (UCSC)Chr 7: 130.21 – 130.22 MbChr 6: 30.51 – 30.52 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Gene

The gene and intron-exon structure were first predicted through analysis of the complete sequence of human chromosome 7, its initial designation being C7orf45.[6][7] Human mRNA transcripts were identified through two large scale cDNA cloning efforts, an American effort run out of the Dana-Farber Cancer Institute and Harvard Medical School, and full-length long Japan effort. Later assigned the official symbol SSMEM1, the gene is located on the long arm of chromosome 7 (7q32.2) on the sense strand in humans.[8] The human mRNA transcript is 1171 bp long with three exons.[9]

Aliases

In humans, SSMEM1 is also referred to as C7orf45.[8] Human SSMEM1 has a clone name of FLJ40316.[8]

Expression

In humans, SSMEM1 is highly expressed in the testes.[10][11][12] In mice, SSMEM1 is expressed in the brain.[13]

Protein

In humans, serine-rich single pass membrane protein 1 is 244 amino acids long with a transmembrane domain region spanning amino acids 35-55.[5] This protein has a domain of unknown function (DUF4636) that spans almost all of the protein (amino acids 1-243).[5] DUF4636 belongs to pfam15468 which is a part of the superfamily cl21285 that is found in eukaryotes and typically 196 to 244 amino acids long.[5] The human protein has a molecular weight of 28036 Da and an isoelectric point of 7.64.[5][14]

References
  1. GRCh38: Ensembl release 89: ENSG00000165120 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000029784 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "serine-rich single-pass membrane protein 1 [Homo sapiens]". Protein. NCBI. 26 August 2016. NP_660311.1. Retrieved 2016-12-16.
  6. "Showing 9.782 kbp from Chr7, positions 129,233,084 to 129,242,865". The Chromosome 7 Annotation Project. June 2004. Landmark or Region: Gene:C7orf45|NM_145268.2. Retrieved 2016-12-16.
  7. Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human Chromosome 7: DNA Sequence and Biology". Science. 300 (5620): 767–772. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
  8. "SSMEM1 serine rich single-pass membrane protein 1 [ Homo sapiens (human) ]". Gene. NCBI. 6 December 2016. 136263. Retrieved 2016-12-16.
  9. "Homo sapiens serine rich single-pass membrane protein 1 (SSMEM1), mRNA". Nucleotide. NCBI. 26 August 2016. NM_145268.3. Retrieved 2016-12-16.
  10. "United States Patent: 8586006 - Organ-specific proteins and methods of their use".
  11. "Est Profile - Hs.351816". UniGene. NCBI. 2016.
  12. "GDS3834 / 4246". www.ncbi.nlm.nih.gov. Retrieved 2016-12-17.
  13. "Gene Detail :: Allen Brain Atlas: Mouse Brain". mouse.brain-map.org. Retrieved 2016-12-17.
  14. "SSMEM1 (human)". www.phosphosite.org. Retrieved 2016-12-17.
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