SSR2

Translocon-associated protein subunit beta also known as TRAP-beta is a protein that in humans is encoded by the SSR2 gene.[5][6]

SSR2
Identifiers
Aliases	SSR2, TLAP, TRAP-BETA, TRAPB, HSD25, signal sequence receptor subunit 2
External IDs	OMIM: 600867 MGI: 1913506 HomoloGene: 2369 GeneCards: SSR2
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q22 Start 156,009,048 bp[1] End 156,020,951 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 F1 Start 88,575,876 bp[2] End 88,588,419 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding Cellular component • integral component of membrane • endoplasmic reticulum membrane • endoplasmic reticulum • membrane Biological process • cotranslational protein targeting to membrane Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6746	66256
Ensembl	ENSG00000163479	ENSMUSG00000041355
UniProt	P43308	Q9CPW5
RefSeq (mRNA)	NM_003145	NM_025448
RefSeq (protein)	NP_003136	NP_079724 NP_001343245 NP_001343246 NP_001343247 NP_001343248
Location (UCSC)	Chr 1: 156.01 – 156.02 Mb	Chr 3: 88.58 – 88.59 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The signal sequence receptor (SSR) is a glycosylated endoplasmic reticulum (ER) membrane receptor associated with protein translocation across the ER membrane. The SSR consists of 2 subunits, a 34-kD glycoprotein (alpha-SSR or SSR1) and a 22-kD glycoprotein (beta-SSR or SSR2). The human beta-signal sequence receptor gene (SSR2) maps to chromosome bands 1q21-q23.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000163479 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000041355 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Chinen K, Sudo K, Takahashi E, Nakamura Y (Jul 1995). "Isolation and mapping of the human beta-signal sequence receptor gene (SSR2)". Cytogenetics and Cell Genetics. 70 (3–4): 215–7. doi:10.1159/000134036. PMID 7789174.
6. "Entrez Gene: SSR2 signal sequence receptor, beta (translocon-associated protein beta)".

Further reading

• Tajima S, Lauffer L, Rath VL, Walter P (October 1986). "The signal recognition particle receptor is a complex that contains two distinct polypeptide chains". The Journal of Cell Biology. 103 (4): 1167–78. doi:10.1083/jcb.103.4.1167. PMC 2114348. PMID 3021779.
• Hartmann E, Görlich D, Kostka S, Otto A, Kraft R, Knespel S, Bürger E, Rapoport TA, Prehn S (June 1993). "A tetrameric complex of membrane proteins in the endoplasmic reticulum". European Journal of Biochemistry / FEBS. 214 (2): 375–81. doi:10.1111/j.1432-1033.1993.tb17933.x. hdl:11858/00-001M-0000-0015-3BD2-F. PMID 7916687.
• Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Bodescot M, Brison O (January 1994). "Cloning and sequence analysis of the beta subunit of the human translocon-associated protein". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1217 (1): 101–2. doi:10.1016/0167-4781(94)90131-7. PMID 8286409.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Wang L, Dobberstein B (September 1999). "Oligomeric complexes involved in translocation of proteins across the membrane of the endoplasmic reticulum". FEBS Letters. 457 (3): 316–22. doi:10.1016/S0014-5793(99)01075-3. PMID 10471800.
• Zhang H, Li XJ, Martin DB, Aebersold R (June 2003). "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry". Nature Biotechnology. 21 (6): 660–6. doi:10.1038/nbt827. PMID 12754519. S2CID 581283.
• Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S (September 2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Research. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.