SSX5

Protein SSX5 is a protein that in humans is encoded by the SSX5 gene.[3]

SSX5
Identifiers
Aliases	SSX5, SSX family member 5
External IDs	OMIM: 300327 HomoloGene: 137346 GeneCards: SSX5
Gene location (Human) Chr. X chromosome (human)[1] Band Xp11.23 Start 48,186,220 bp[1] End 48,196,763 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • GO:0001106 transcription corepressor activity • nucleic acid binding Cellular component • intracellular • cell nucleus Biological process • negative regulation of nucleic acid-templated transcription • regulation of transcription, DNA-templated • transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6758	n/a
Ensembl	ENSG00000165583	n/a
UniProt	O60225	n/a
RefSeq (mRNA)	NM_021015 NM_175723	n/a
RefSeq (protein)	NP_066295 NP_783729	n/a
Location (UCSC)	Chr X: 48.19 – 48.2 Mb	n/a
PubMed search	[2]	n/a
Wikidata
View/Edit Human

Function

The product of this gene belongs to the family of highly homologous synovial sarcoma, X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneously humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. SSX1, SSX2 and SSX4 genes have been involved in the t(X;18) chromosomal translocation characteristically found in all synovial sarcomas. This gene appears not to be involved in this type of translocation. Two transcript variants encoding distinct isoforms have been identified for this gene.[3]

References

1. GRCh38: Ensembl release 89: ENSG00000165583 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Entrez Gene: SSX5 synovial sarcoma, X breakpoint 5".

Further reading

• dos Santos NR, de Bruijn DR, van Kessel AG (January 2001). "Molecular mechanisms underlying human synovial sarcoma development". Genes, Chromosomes & Cancer. 30 (1): 1–14. doi:10.1002/1098-2264(2000)9999:9999<::AID-GCC1056>3.0.CO;2-G. PMID 11107170.
• Gure AO, Türeci O, Sahin U, Tsang S, Scanlan MJ, Jäger E, Knuth A, Pfreundschuh M, Old LJ, Chen YT (September 1997). "SSX: a multigene family with several members transcribed in normal testis and human cancer". International Journal of Cancer. 72 (6): 965–71. doi:10.1002/(SICI)1097-0215(19970917)72:6<965::AID-IJC8>3.0.CO;2-N. PMID 9378559.
• Chen CH, Chen GJ, Lee HS, Huang GT, Yang PM, Tsai LJ, Chen DS, Sheu JC (March 2001). "Expressions of cancer-testis antigens in human hepatocellular carcinomas". Cancer Letters. 164 (2): 189–95. doi:10.1016/S0304-3835(01)00379-2. PMID 11179834.
• de Bruijn DR, dos Santos NR, Kater-Baats E, Thijssen J, van den Berk L, Stap J, Balemans M, Schepens M, Merkx G, van Kessel AG (July 2002). "The cancer-related protein SSX2 interacts with the human homologue of a Ras-like GTPase interactor, RAB3IP, and a novel nuclear protein, SSX2IP". Genes, Chromosomes & Cancer. 34 (3): 285–98. doi:10.1002/gcc.10073. PMID 12007189.
• Güre AO, Wei IJ, Old LJ, Chen YT (October 2002). "The SSX gene family: characterization of 9 complete genes". International Journal of Cancer. 101 (5): 448–53. doi:10.1002/ijc.10634. PMID 12216073.
• Wu LQ, Lu Y, Wang XF, Lv ZH, Zhang B, Yang JY (July 2006). "Expression of cancer-testis antigen (CTA) in tumor tissues and peripheral blood of Chinese patients with hepatocellular carcinoma". Life Sciences. 79 (8): 744–8. doi:10.1016/j.lfs.2006.02.024. PMID 16546222.