ST6GALNAC1

Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 is an enzyme that in humans is encoded by the ST6GALNAC1 gene.[5] This enzyme adds a N-Acetylneuraminic acid (Sialic Acid/Neu5Ac) to an O-linked N-Acetylgalactosamine (GalNAc) on a peptide/proteins (also called Tn antigen) with an α2-6 linkage to produce the sialyl-Tn antigen. It has been shown that the enzyme prefers Thr over Ser containing GalNAc residues.[6][7]

ST6GALNAC1
Identifiers
Aliases	ST6GALNAC1, HSY11339, SIAT7A, ST6GalNAcI, STYI, ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 1
External IDs	OMIM: 610138 MGI: 1341826 HomoloGene: 7937 GeneCards: ST6GALNAC1
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q25.1 Start 76,624,761 bp[1] End 76,643,786 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 E2 Start 116,765,025 bp[2] End 116,775,507 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • transferase activity • sialyltransferase activity • transferase activity, transferring glycosyl groups • alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity Cellular component • integral component of membrane • Golgi apparatus • membrane • Golgi membrane Biological process • sialylation • protein glycosylation • oligosaccharide biosynthetic process • oligosaccharide metabolic process • protein N-linked glycosylation via asparagine • ganglioside biosynthetic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	55808	20445
Ensembl	ENSG00000070526	ENSMUSG00000009588
UniProt	Q9NSC7	Q9QZ39
RefSeq (mRNA)	NM_001289107 NM_018414	NM_011371
RefSeq (protein)	NP_001276036 NP_060884	NP_035501
Location (UCSC)	Chr 17: 76.62 – 76.64 Mb	Chr 11: 116.77 – 116.78 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000070526 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000009588 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: ST6GALNAC1 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1".
6. Mehta AY, Veeraiah RK, Dutta S, Goth CK, Hanes MS, Gao C, et al. (June 2020). "Parallel Glyco-SPOT Synthesis of Glycopeptide Libraries". Cell Chemical Biology. 27 (9): 1207–1219.e9. doi:10.1016/j.chembiol.2020.06.007. PMID 32610041.
7. Yoshimura Y, Denda-Nagai K, Takahashi Y, Nagashima I, Shimizu H, Kishimoto T, et al. (November 2019). "Products of Chemoenzymatic Synthesis Representing MUC1 Tandem Repeat Unit with T-, ST- or STn-antigen Revealed Distinct Specificities of Anti-MUC1 Antibodies". Scientific Reports. 9 (1): 16641. doi:10.1038/s41598-019-53052-1. PMC 6851390. PMID 31719620.

Further reading

• Lee YC, Kaufmann M, Kitazume-Kawaguchi S, Kono M, Takashima S, Kurosawa N, Liu H, Pircher H, Tsuji S (April 1999). "Molecular cloning and functional expression of two members of mouse NeuAcalpha2,3Galbeta1,3GalNAc GalNAcalpha2,6-sialyltransferase family, ST6GalNAc III and IV". The Journal of Biological Chemistry. 274 (17): 11958–67. doi:10.1074/jbc.274.17.11958. PMID 10207017.
• Ikehara Y, Kojima N, Kurosawa N, Kudo T, Kono M, Nishihara S, Issiki S, Morozumi K, Itzkowitz S, Tsuda T, Nishimura SI, Tsuji S, Narimatsu H (November 1999). "Cloning and expression of a human gene encoding an N-acetylgalactosamine-alpha2,6-sialyltransferase (ST6GalNAc I): a candidate for synthesis of cancer-associated sialyl-Tn antigens". Glycobiology. 9 (11): 1213–24. doi:10.1093/glycob/9.11.1213. PMID 10536037.
• Donadio S, Dubois C, Fichant G, Roybon L, Guillemot JC, Breton C, Ronin C (2004). "Recognition of cell surface acceptors by two human alpha-2,6-sialyltransferases produced in CHO cells". Biochimie. 85 (3–4): 311–21. doi:10.1016/S0300-9084(03)00080-4. PMID 12770770.
• Julien S, Krzewinski-Recchi MA, Harduin-Lepers A, Gouyer V, Huet G, Le Bourhis X, Delannoy P (2003). "Expression of sialyl-Tn antigen in breast cancer cells transfected with the human CMP-Neu5Ac: GalNAc alpha2,6-sialyltransferase (ST6GalNac I) cDNA". Glycoconjugate Journal. 18 (11–12): 883–93. doi:10.1023/A:1022200525695. PMID 12820722. S2CID 21051703.
• Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A (October 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Research. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Sewell R, Bäckström M, Dalziel M, Gschmeissner S, Karlsson H, Noll T, Gätgens J, Clausen H, Hansson GC, Burchell J, Taylor-Papadimitriou J (February 2006). "The ST6GalNAc-I sialyltransferase localizes throughout the Golgi and is responsible for the synthesis of the tumor-associated sialyl-Tn O-glycan in human breast cancer". The Journal of Biological Chemistry. 281 (6): 3586–94. doi:10.1074/jbc.M511826200. PMID 16319059.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.