ST6GALNAC6

Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 is an enzyme that in humans is encoded by the ST6GALNAC6 gene.[5][6]

ST6GALNAC6
Identifiers
Aliases	ST6GALNAC6, SIAT7-F, SIAT7F, ST6GALNACVI, ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
External IDs	OMIM: 610135 MGI: 1355316 HomoloGene: 8390 GeneCards: ST6GALNAC6
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q34.11 Start 127,885,321 bp[1] End 127,905,408 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 B Start 32,599,709 bp[2] End 32,620,806 bp[2]
Gene ontology Molecular function • transferase activity • transferase activity, transferring glycosyl groups • sialyltransferase activity • alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity Cellular component • integral component of membrane • Golgi apparatus • membrane • cell membrane • Golgi membrane • cytoplasm Biological process • cell-cell recognition • glycoprotein metabolic process • glycosphingolipid metabolic process • protein glycosylation • glycosylceramide metabolic process • oligosaccharide metabolic process • sialylation • protein N-linked glycosylation via asparagine • ganglioside biosynthetic process • oligosaccharide biosynthetic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	30815	50935
Ensembl	ENSG00000160408	ENSMUSG00000026811
UniProt	Q969X2	Q9JM95
RefSeq (mRNA)	NM_001286999 NM_001287000 NM_001287001 NM_001287002 NM_001287003 NM_013443	NM_001025310 NM_001025311 NM_001289547 NM_001289548 NM_001289549 NM_016973
RefSeq (protein)	NP_001273928 NP_001273929 NP_001273930 NP_001273931 NP_001273932 NP_038471	NP_001020481 NP_001020482 NP_001276476 NP_001276477 NP_001276478 NP_058669
Location (UCSC)	Chr 9: 127.89 – 127.91 Mb	Chr 2: 32.6 – 32.62 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000160408 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026811 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Tsuchida A, Okajima T, Furukawa K, Ando T, Ishida H, Yoshida A, Nakamura Y, Kannagi R, Kiso M, Furukawa K (Jun 2003). "Synthesis of disialyl Lewis a (Le(a)) structure in colon cancer cell lines by a sialyltransferase, ST6GalNAc VI, responsible for the synthesis of alpha-series gangliosides". J Biol Chem. 278 (25): 22787–94. doi:10.1074/jbc.M211034200. PMID 12668675.
6. "Entrez Gene: ST6GALNAC6 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6".

Further reading

• Senda M, Ito A, Tsuchida A, et al. (2007). "Identification and expression of a sialyltransferase responsible for the synthesis of disialylgalactosylgloboside in normal and malignant kidney cells: downregulation of ST6GalNAc VI in renal cancers". Biochem. J. 402 (3): 459–70. doi:10.1042/BJ20061118. PMC 1863573. PMID 17123352.
• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
• Harduin-Lepers A, Mollicone R, Delannoy P, Oriol R (2005). "The animal sialyltransferases and sialyltransferase-related genes: a phylogenetic approach". Glycobiology. 15 (8): 805–17. doi:10.1093/glycob/cwi063. PMID 15843597.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Okajima T, Chen HH, Ito H, et al. (2000). "Molecular cloning and expression of mouse GD1alpha/GT1aalpha/GQ1balpha synthase (ST6GalNAc VI) gene". J. Biol. Chem. 275 (10): 6717–23. doi:10.1074/jbc.275.10.6717. PMID 10702226.