ST8SIA6

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 is a protein that in humans is encoded by the ST8SIA6 gene. [5]

ST8SIA6
Identifiers
Aliases	ST8SIA6, SIA8F, SIAT8F, ST8SIA-VI, ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6, ST8SiaVI, SIAT8-F
External IDs	OMIM: 610139 MGI: 2386797 HomoloGene: 17112 GeneCards: ST8SIA6
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10p12.33 Start 17,318,383 bp[1] End 17,454,330 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 A1 Start 13,651,021 bp[2] End 13,794,064 bp[2]
Gene ontology Molecular function • transferase activity • sialyltransferase activity • transferase activity, transferring glycosyl groups • alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity Cellular component • integral component of membrane • Golgi membrane • Golgi apparatus • membrane Biological process • glycolipid biosynthetic process • sialylation • protein glycosylation • protein O-linked glycosylation • glycoprotein metabolic process • oligosaccharide metabolic process • ganglioside biosynthetic process • carbohydrate biosynthetic process • blastocyst hatching Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	338596	241230
Ensembl	ENSG00000148488	ENSMUSG00000003418
UniProt	P61647	Q8K4T1
RefSeq (mRNA)	NM_001004470 NM_001345961	NM_145838
RefSeq (protein)	NP_001004470 NP_001332890	NP_665837
Location (UCSC)	Chr 10: 17.32 – 17.45 Mb	Chr 2: 13.65 – 13.79 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

Sialic acid is a key determinate of oligosaccharide structures involved in cell-cell communication, cell-substrate interaction, adhesion, and protein targeting. ST8SIA6 belongs to a family of sialyltransferases (EC 2.4.99.8) that synthesize sialylglycoconjugates (Takashima et al., 2002 [PubMed 11980897]).

References

1. GRCh38: Ensembl release 89: ENSG00000148488 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000003418 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6". Retrieved 2017-02-02.

Further reading

• Avril T, North SJ, Haslam SM, Willison HJ, Crocker PR (2006). "Probing the cis interactions of the inhibitory receptor Siglec-7 with alpha2,8-disialylated ligands on natural killer cells and other leukocytes using glycan-specific antibodies and by analysis of alpha2,8-sialyltransferase gene expression". J. Leukoc. Biol. 80 (4): 787–96. doi:10.1189/jlb.1005559. PMID 16857734. S2CID 7578193.
• Szabo R, Skropeta D, et al. (2017). "Advancement of Sialyltransferase Inhibitors: Therapeutic Challenges and Opportunities". Med. Res. Rev. 37 (2): 210–270. doi:10.1002/med.21407. PMID 27678392. S2CID 26280291.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.