STAG1

Cohesin subunit SA-1 (SA1) is a protein that in humans is encoded by the STAG1 gene.[5][6] SA2 is a subunit of the Cohesin complex which mediates sister chromatid cohesion, homologous recombination and DNA looping. In somatic cells cohesin is formed of SMC3, SMC1, RAD21 and either SA1 or SA2 whereas in meiosis, cohesin is formed of SMC3, SMC1B, REC8 and SA3.

Structure of SA2 (blue) and RAD21 (green) (PDB 4PK7)

STAG1
Identifiers
Aliases	STAG1, SA1, SCC3A, stromal antigen 1, MRD47
External IDs	OMIM: 604358 MGI: 1098658 HomoloGene: 21191 GeneCards: STAG1
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q22.3 Start 136,336,236 bp[1] End 136,752,403 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 E3.3-E4 Start 100,597,798 bp[2] End 100,959,375 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • chromatin binding • GO:0001948 protein binding Cellular component • chromosome • cytosol • chromatin • chromosome, centromeric region • cell nucleus • nucleoplasm • nuclear body • cohesin complex • nuclear matrix • mitotic spindle pole Biological process • chromosome segregation • cell division • cell cycle • transcription from RNA polymerase II promoter • positive regulation of transcription from RNA polymerase II promoter • regulation of mitotic spindle assembly • sister chromatid cohesion Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10274	20842
Ensembl	ENSG00000118007	ENSMUSG00000037286
UniProt	Q8WVM7	Q9D3E6
RefSeq (mRNA)	NM_005862	NM_009282 NM_001357264 NM_001357265
RefSeq (protein)	NP_005853	NP_033308 NP_001344193 NP_001344194
Location (UCSC)	Chr 3: 136.34 – 136.75 Mb	Chr 9: 100.6 – 100.96 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Structure and Interactions

SA1 is one of three human homologues of the yeast protein Scc3 which is a core subunit of the cohesin complex (the three human paralogues are SA1, SA2 and SA3). SA1 and SA2 are expressed in somatic cells whereas SA3 is the main SA paralogue in meiotic cells. SA1 stably binds to cohesin via the RAD21 subunit and functions as a platform for other regulatory subunits. SA1 has roles in regulating both cohesin loading and release. [6]

References

1. GRCh38: Ensembl release 89: ENSG00000118007 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000037286 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Carramolino L, Lee BC, Zaballos A, Peled A, Barthelemy I, Shav-Tal Y, Prieto I, Carmi P, Gothelf Y, González de Buitrago G, Aracil M, Márquez G, Barbero JL, Zipori D (August 1997). "SA-1, a nuclear protein encoded by one member of a novel gene family: molecular cloning and detection in hemopoietic organs". Gene. 195 (2): 151–9. doi:10.1016/S0378-1119(97)00121-2. PMID 9305759.
6. "Entrez Gene: STAG1 stromal antigen 1".

External links

• STAG1 human gene location in the UCSC Genome Browser.
• STAG1 human gene details in the UCSC Genome Browser.