STAP2

Signal-transducing adaptor protein 2 is a protein that in humans is encoded by the STAP2 gene.[5][6][7]

STAP2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2EL8
Identifiers
Aliases	STAP2, BKS, signal transducing adaptor family member 2
External IDs	OMIM: 607881 MGI: 2147039 HomoloGene: 9798 GeneCards: STAP2
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.3 Start 4,324,043 bp[1] End 4,342,786 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 D Start 55,997,077 bp[2] End 56,005,584 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • signaling adaptor activity Cellular component • cytoplasm • cytosol • cell membrane Biological process • positive regulation of tyrosine phosphorylation of STAT protein • positive regulation of signal transduction Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	55620	106766
Ensembl	ENSG00000178078	ENSMUSG00000038781
UniProt	Q9UGK3	Q8R0L1
RefSeq (mRNA)	NM_001013841 NM_017720	NM_145934
RefSeq (protein)	NP_001013863 NP_060190	NP_666046
Location (UCSC)	Chr 19: 4.32 – 4.34 Mb	Chr 17: 56 – 56.01 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes the substrate of breast tumor kinase, an Src-type non-receptor tyrosine kinase. The encoded protein possesses domains and several tyrosine phosphorylation sites characteristic of adaptor proteins that mediate the interactions linking proteins involved in signal transduction pathways. Alternative splicing results in multiple transcript variants.[7]

Interactions

STAP2 has been shown to interact with PTK6.[5]

References

1. GRCh38: Ensembl release 89: ENSG00000178078 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000038781 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Mitchell PJ, Sara EA, Crompton MR (Oct 2000). "A novel adaptor-like protein which is a substrate for the non-receptor tyrosine kinase, BRK". Oncogene. 19 (37): 4273–82. doi:10.1038/sj.onc.1203775. PMID 10980601.
6. Dehal P, Predki P, Olsen AS, Kobayashi A, Folta P, Lucas S, Land M, Terry A, Ecale Zhou CL, Rash S, Zhang Q, Gordon L, Kim J, Elkin C, Pollard MJ, Richardson P, Rokhsar D, Uberbacher E, Hawkins T, Branscomb E, Stubbs L (Jul 2001). "Human chromosome 19 and related regions in mouse: conservative and lineage-specific evolution". Science. 293 (5527): 104–11. doi:10.1126/science.1060310. PMID 11441184. S2CID 826987.
7. "Entrez Gene: STAP2 signal-transducing adaptor protein-2".

Further reading

• Rosenzweig BL, Imamura T, Okadome T, et al. (1995). "Cloning and characterization of a human type II receptor for bone morphogenetic proteins". Proc. Natl. Acad. Sci. U.S.A. 92 (17): 7632–6. doi:10.1073/pnas.92.17.7632. PMC 41199. PMID 7644468.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Minoguchi M, Minoguchi S, Aki D, et al. (2003). "STAP-2/BKS, an adaptor/docking protein, modulates STAT3 activation in acute-phase response through its YXXQ motif". J. Biol. Chem. 278 (13): 11182–9. doi:10.1074/jbc.M211230200. PMID 12540842.
• Yamamoto T, Yumioka T, Sekine Y, et al. (2003). "Regulation of FcepsilonRI-mediated signaling by an adaptor protein STAP-2/BSK in rat basophilic leukemia RBL-2H3 cells". Biochem. Biophys. Res. Commun. 306 (3): 767–73. doi:10.1016/S0006-291X(03)01042-8. PMID 12810085.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Sekine Y, Yamamoto T, Yumioka T, et al. (2005). "Physical and functional interactions between STAP-2/BKS and STAT5". J. Biol. Chem. 280 (9): 8188–96. doi:10.1074/jbc.M411692200. PMID 15611091.
• Sekine Y, Tsuji S, Ikeda O, et al. (2007). "Signal-transducing adaptor protein-2 regulates integrin-mediated T cell adhesion through protein degradation of focal adhesion kinase". J. Immunol. 179 (4): 2397–407. doi:10.4049/jimmunol.179.4.2397. PMID 17675501.