STARD3NL

MENTHO or STARD3 N-terminal like protein (STARD3NL) is an integral membrane protein of unknown function.[5] As the alternate name implies, MENTHO, short for "MLN64 N-terminal homologue", contains a region in its N-terminus similar to that found in STARD3, also known as MLN64, but lacks the StAR-related transfer domain (START) that characterizes all other proteins given the "STARD" (START domain-containing) name. The N-terminal domain is called a MENTAL (MLN64 N-terminal) domain.

STARD3NL
Identifiers
Aliases	STARD3NL, MENTHO, STARD3 N-terminal like
External IDs	OMIM: 611759 MGI: 1923455 HomoloGene: 11501 GeneCards: STARD3NL
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7p14.1 Start 38,178,222 bp[1] End 38,230,671 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 A2 Start 19,357,676 bp[2] End 19,395,795 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • cholesterol binding • protein homodimerization activity Cellular component • lysosomal membrane • membrane • integral component of membrane • endosome • cytosol • intracellular membrane-bounded organelle • endoplasmic reticulum membrane • late endosome membrane • organelle membrane contact site • endoplasmic reticulum-endosome membrane contact site Biological process • C21-steroid hormone biosynthetic process • vesicle tethering to endoplasmic reticulum Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	83930	76205
Ensembl	ENSG00000010270	ENSMUSG00000003062
UniProt	O95772	Q9DCI3
RefSeq (mRNA)	NM_032016 NM_001363339 NM_001363340 NM_001363343 NM_001363344 NM_001363345 NM_001363346 NM_001363347	NM_024270 NM_001347485
RefSeq (protein)	NP_114405 NP_001350268 NP_001350269 NP_001350272 NP_001350273 NP_001350274 NP_001350275 NP_001350276	NP_001334414 NP_077232
Location (UCSC)	Chr 7: 38.18 – 38.23 Mb	Chr 13: 19.36 – 19.4 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Like MLN64, MENTHO is widely expressed in tissues of the body. Within the cell, it localizes to the membranes of late endosomes and may interact there with MLN64. It is suggested that in combination with MLN64, this protein helps regulate the flow of cholesterol through the endosomal pathway.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000010270 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000003062 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: STARD3NL STARD3 N-terminal like".
6. Alpy F, Tomasetto C (2006). "MLN64 and MENTHO, two mediators of endosomal cholesterol transport". Biochem. Soc. Trans. 34 (Pt 3): 343–5. doi:10.1042/BST0340343. PMID 16709157.

Further reading

• Sanger Centre, The; Washington University Genome Sequencing Cente, The (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.
• Alpy F, Wendling C, Rio MC, Tomasetto C (2003). "MENTHO, an MLN64 homologue devoid of the START domain". J. Biol. Chem. 277 (52): 50780–7. doi:10.1074/jbc.M208290200. PMID 12393907.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
• Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Tuckey RC, Bose HS, Czerwionka I, Miller WL (2004). "Molten globule structure and steroidogenic activity of N-218 MLN64 in human placental mitochondria". Endocrinology. 145 (4): 1700–7. doi:10.1210/en.2003-1034. PMID 14715710.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Alpy F, Latchumanan VK, Kedinger V, et al. (2005). "Functional characterization of the MENTAL domain". J. Biol. Chem. 280 (18): 17945–52. doi:10.1074/jbc.M500723200. PMID 15718238.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

External links

• STARD3NL+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)