STARD7

STARD7
Identifiers
Aliases	STARD7, GTT1, StAR related lipid transfer domain containing 7, FAME2
External IDs	OMIM: 616712 MGI: 2139090 HomoloGene: 32463 GeneCards: STARD7
Gene location (Human)
Chr.	Chromosome 2 (human)[1]
End	96,208,825 bp[1]
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)[2]
End	127,298,932 bp[2]
Gene ontology
Molecular function	• lipid binding; • phospholipid transporter activity;
Cellular component	• mitochondrion; • mitochondrial outer membrane;
Biological process	• phosphatidylcholine biosynthetic process; • phospholipid transport;
	Sources:Amigo / QuickGO
Orthologs
	56910
	99138
	ENSG00000084090
	ENSMUSG00000027367
	Q9NQZ5
	Q8R1R3
	NM_020151; NM_139267
	NM_139308; NM_001362684
	NP_064536
	NP_647469; NP_001349613
	Wikidata
View/Edit Human	View/Edit Mouse

StAR-related lipid transfer domain protein 7 (STARD7) or gestational trophoblastic tumor gene-1 (GTT1) is a lipid transporter that specifically binds and transports phosphatidylcholine between membranes.[5]

Function and tissue distribution

StarD7 is found in the cytosol and associated with the mitochondrion.[5] When overproduced in the cell, mitochondrial levels of phosphatidylcholine rise.[5] High levels of the protein are found in tumor cells compared to normal cells, suggesting a role in cell proliferation.[6]

Structure

There are two forms of StarD7: StarD7-I and StarD7-II. The former is 295 amino acids long. StarD7-I possesses an additional 75 amino acids at its amino-terminus, which form a signaling sequence that targets it to the outer membrane of the mitochondrion.[5]

StarD7 contains a StAR-related transfer domain (START), from which it derives its name. Moreover, the protein is a member of the predominantly phosphatidylcholine transporter subfamily of START proteins, the StarD2 subfamily. It shares 25% sequence identity with StarD2.[5]

References

GRCh38: Ensembl release 89: ENSG00000084090 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000027367 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Horibata Y, Sugimoto H (March 2010). "StarD7 mediates the intracellular trafficking of phosphatidylcholine to mitochondria". The Journal of Biological Chemistry. 285 (10): 7358–65. doi:10.1074/jbc.M109.056960. PMC 2844184. PMID 20042613.
Durand S, Angeletti S, Genti-Raimondi S (January 2004). "GTT1/StarD7, a novel phosphatidylcholine transfer protein-like highly expressed in gestational trophoblastic tumour: cloning and characterization". Placenta. 25 (1): 37–44. doi:10.1016/S0143-4004(03)00214-5. PMID 15013637.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000084090 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027367 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid20042613-5] Horibata Y, Sugimoto H (March 2010). "StarD7 mediates the intracellular trafficking of phosphatidylcholine to mitochondria". The Journal of Biological Chemistry. 285 (10): 7358–65. doi:10.1074/jbc.M109.056960. PMC 2844184. PMID 20042613.

[pmid15013637-6] Durand S, Angeletti S, Genti-Raimondi S (January 2004). "GTT1/StarD7, a novel phosphatidylcholine transfer protein-like highly expressed in gestational trophoblastic tumour: cloning and characterization". Placenta. 25 (1): 37–44. doi:10.1016/S0143-4004(03)00214-5. PMID 15013637.