STAT5B

Signal transducer and activator of transcription 5B is a protein that in humans is encoded by the STAT5B gene.[5] STAT5B orthologs [6] have been identified in most placentals for which complete genome data are available.

STAT5B
Identifiers
Aliases	STAT5B, STAT5, signal transducer and activator of transcription 5B
External IDs	OMIM: 604260 MGI: 103035 HomoloGene: 55718 GeneCards: STAT5B
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q21.2 Start 42,199,177 bp[1] End 42,276,707 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 D|11 63.63 cM Start 100,780,731 bp[2] End 100,850,724 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • signal transducer activity • glucocorticoid receptor binding • protein dimerization activity • chromatin binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • DNA binding • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • GO:0001948 protein binding • protein tyrosine kinase activity • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component • nucleoplasm • cytoplasm • cell nucleus • cytosol Biological process • positive regulation of natural killer cell differentiation • positive regulation of natural killer cell mediated cytotoxicity • regulation of steroid metabolic process • creatinine metabolic process • T cell differentiation in thymus • female pregnancy • cellular response to hormone stimulus • positive regulation of activated T cell proliferation • progesterone metabolic process • JAK-STAT cascade • negative regulation of apoptotic process • Peyer's patch development • transcription, DNA-templated • signal transduction • cellular response to growth factor stimulus • natural killer cell differentiation • response to interleukin-4 • sex differentiation • valine metabolic process • positive regulation of B cell differentiation • T cell homeostasis • creatine metabolic process • cellular response to epidermal growth factor stimulus • response to estradiol • positive regulation of inflammatory response • regulation of transcription from RNA polymerase II promoter • mast cell migration • positive regulation of mitotic cell cycle • lipid storage • development of secondary female sexual characteristics • fatty acid metabolic process • taurine metabolic process • succinate metabolic process • positive regulation of gamma-delta T cell differentiation • positive regulation of lymphocyte differentiation • regulation of multicellular organism growth • citrate metabolic process • positive regulation of cell proliferation • oxaloacetate metabolic process • regulation of epithelial cell differentiation • positive regulation of natural killer cell proliferation • development of secondary male sexual characteristics • positive regulation of multicellular organism growth • regulation of transcription, DNA-templated • allantoin metabolic process • positive regulation of transcription from RNA polymerase II promoter • transcription from RNA polymerase II promoter • luteinization • isoleucine metabolic process • negative regulation of erythrocyte differentiation • lactation • response to interleukin-15 • regulation of cell adhesion • 2-oxoglutarate metabolic process • response to interleukin-2 • JAK-STAT cascade involved in growth hormone signaling pathway • positive regulation of erythrocyte differentiation • peptidyl-tyrosine phosphorylation • interleukin-7-mediated signaling pathway • interleukin-15-mediated signaling pathway • cytokine-mediated signaling pathway • interleukin-2-mediated signaling pathway • interleukin-9-mediated signaling pathway • defense response • regulation of cell proliferation • response to peptide hormone Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6777	20851
Ensembl	ENSG00000173757	ENSMUSG00000020919
UniProt	P51692	P42232
RefSeq (mRNA)	NM_012448	NM_001113563 NM_011489 NM_001362682
RefSeq (protein)	NP_036580	NP_001107035 NP_035619 NP_001349611
Location (UCSC)	Chr 17: 42.2 – 42.28 Mb	Chr 11: 100.78 – 100.85 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APML). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APML.[7]

Interactions

STAT5B has been shown to interact with:

• Glucocorticoid receptor,[8]
• Janus kinase 1,[9]
• Janus kinase 2,[9][10] and
• PTPN11.[11]

See also

• STAT5

References

1. GRCh38: Ensembl release 89: ENSG00000173757 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020919 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Lin JX, Mietz J, Modi WS, John S, Leonard WJ (July 1996). "Cloning of human Stat5B. Reconstitution of interleukin-2-induced Stat5A and Stat5B DNA binding activity in COS-7 cells". J. Biol. Chem. 271 (18): 10738–44. doi:10.1074/jbc.271.18.10738. PMID 8631883.
6. "OrthoMaM phylogenetic marker: STAT5B coding sequence".
7. "Entrez Gene: STAT5B signal transducer and activator of transcription 5B".
8. Stöcklin E, Wissler M, Gouilleux F, Groner B (October 1996). "Functional interactions between Stat5 and the glucocorticoid receptor". Nature. 383 (6602): 726–8. doi:10.1038/383726a0. PMID 8878484. S2CID 4356272.
9. Fujitani Y, Hibi M, Fukada T, Takahashi-Tezuka M, Yoshida H, Yamaguchi T, Sugiyama K, Yamanaka Y, Nakajima K, Hirano T (February 1997). "An alternative pathway for STAT activation that is mediated by the direct interaction between JAK and STAT". Oncogene. 14 (7): 751–61. doi:10.1038/sj.onc.1200907. PMID 9047382.
10. Barahmand-Pour F, Meinke A, Groner B, Decker T (May 1998). "Jak2-Stat5 interactions analyzed in yeast". J. Biol. Chem. 273 (20): 12567–75. doi:10.1074/jbc.273.20.12567. PMID 9575217.
11. Yu CL, Jin YJ, Burakoff SJ (January 2000). "Cytosolic tyrosine dephosphorylation of STAT5. Potential role of SHP-2 in STAT5 regulation". J. Biol. Chem. 275 (1): 599–604. doi:10.1074/jbc.275.1.599. PMID 10617656.

Further reading

• Kisseleva T, Bhattacharya S, Braunstein J, Schindler CW (2002). "Signaling through the JAK/STAT pathway, recent advances and future challenges". Gene. 285 (1–2): 1–24. doi:10.1016/S0378-1119(02)00398-0. PMID 12039028.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.